{"id":"W2583786955","doi":"10.1093/neuonc/nov209.14","title":"CBIO-14TARGETING PROTEASOME ACTIVITY WITH MARIZOMIB AS A THERAPEUTIC PERSPECTIVE FOR GLIOMA PATIENTS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Proteasome; Glioma; Cancer research; Proteasome inhibitor; Bortezomib; In vitro; Biology; Tolerability; Pharmacology; Immunology; Multiple myeloma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400067,0.0002744416,0.0003685338,0.0002137177,0.000107596,0.0004700258,0.0002488033,0.0002627396,0.001587285],"category_scores_gemma":[0.00009056519,0.00007955298,0.0002417711,0.0001933033,0.0001685373,0.0001615946,0.0001493137,0.0005452585,0.0004464489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006119072,"about_ca_system_score_gemma":0.0004381957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127165,"about_ca_topic_score_gemma":0.004057599,"domain_scores_codex":[0.9999633,0.000006360806,0.000002579673,0.00000618008,0.000006465067,0.00001505781],"domain_scores_gemma":[0.9999675,0.000002797249,0.000006350728,0.00000189347,0.000006894939,0.00001456658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00624765,0.0008918691,0.01455829,0.001109236,0.0002360652,0.001907121,0.0001533923,0.001053181,0.1908369,0.003094441,0.02778999,0.7521219],"study_design_scores_gemma":[0.005440172,0.01923173,0.1084999,0.0008616382,0.001327981,0.01853933,0.0005676125,0.006430528,0.192274,0.006043157,0.6406515,0.0001324253],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6213367,0.3177306,0.006883678,0.02621717,0.001036598,0.0002834438,0.0007463634,0.0007563223,0.02500922],"genre_scores_gemma":[0.897912,0.07828097,0.007350361,0.005014614,0.0005477318,0.0001624541,0.001102085,0.00005396647,0.009575877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587285,"threshold_uncertainty_score":0.005309939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663175990436989,"score_gpt":0.2962344963413989,"score_spread":0.269602736437029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}