{"id":"W2583856608","doi":"10.1182/blood.v108.11.3251.3251","title":"Ex Vivo Gene Trasfer for Hemophilia A That Enhances Safety and Results in Sustained In Vivo Factor VIII Expression from Lentivirally-Engineered Endothelial Progenitors.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University","funders":"","keywords":"Matrigel; Genetic enhancement; Ex vivo; In vivo; Progenitor cell; Viral vector; Transgene; Molecular biology; Medicine; Immunology; Biology; Stem cell; Gene; Recombinant DNA; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533167,0.0002725519,0.0001559718,0.0002168031,0.0001112349,0.0003735058,0.0001597769,0.0003018455,0.00120956],"category_scores_gemma":[0.00009736819,0.0001157655,0.0002068897,0.0001047558,0.0001822448,0.0002022954,0.0001029335,0.0006919525,0.0003028671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002082491,"about_ca_system_score_gemma":0.0001612554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002516941,"about_ca_topic_score_gemma":0.0004057056,"domain_scores_codex":[0.9998647,0.00002901821,0.00001280691,0.00002191711,0.00004547871,0.00002607054],"domain_scores_gemma":[0.9998975,0.00001774513,0.00003876023,0.00001470584,0.000008425581,0.00002282561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000814604,0.0001412126,0.0001104415,0.00002268109,0.000004869386,0.00003954611,0.00001149244,0.00008368943,0.9976466,0.0001348135,0.0000579056,0.001665316],"study_design_scores_gemma":[0.00005028793,0.001245913,0.00144087,0.000005777227,0.0000212533,0.0004580915,0.000008601223,0.0009551781,0.992831,0.00003409889,0.002945508,0.000003297027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883775,0.001108148,0.008562964,0.0001176695,0.00004591063,0.0001076594,0.0003470176,0.0001411092,0.001192032],"genre_scores_gemma":[0.9899552,0.0006391206,0.005954436,0.00004399028,0.00001589753,0.00006434146,0.000534501,0.00002591017,0.002766619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120956,"threshold_uncertainty_score":0.004046381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057292945470174,"score_gpt":0.2501389509420056,"score_spread":0.2395660214873038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}