{"id":"W2583946286","doi":"10.1056/nejmc1611639","title":"Multidrug-Resistant HIV-1 Infection despite Preexposure Prophylaxis","year":2017,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; St. Michael's Hospital; Maple Leaf Medical Clinic","funders":"","keywords":"Medicine; Human immunodeficiency virus (HIV); Pre-exposure prophylaxis; Multiple drug resistance; Intensive care medicine; Virology; Immunology; Drug resistance; Men who have sex with men; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001418942,0.0003986511,0.001229536,0.0009037751,0.0001876312,0.00005846042,0.000378714,0.0005860857,0.001357472],"category_scores_gemma":[0.003605925,0.0002460263,0.0005200354,0.0001561297,0.0003222269,0.0002121748,0.00005778766,0.004673506,0.00007587949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060241,"about_ca_system_score_gemma":0.0006751863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005913544,"about_ca_topic_score_gemma":0.0001044751,"domain_scores_codex":[0.9961907,0.0003096735,0.00112702,0.0002965047,0.001570412,0.0005057082],"domain_scores_gemma":[0.9963923,0.0002458628,0.001174934,0.0006757519,0.0009372043,0.0005739111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008027902,0.00007577433,0.002156184,0.0006365124,0.0004627465,0.004881585,0.0002757473,7.812393e-7,0.001534436,0.000002434996,0.8502012,0.1389698],"study_design_scores_gemma":[0.02891364,0.03913258,0.002447972,0.006457466,0.0005729659,0.003527533,0.00001598873,0.00002933197,0.0001605229,0.0001175227,0.9184344,0.0001900214],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.03230573,0.005267632,0.002192844,0.9434531,0.001910836,0.001025267,0.00007253678,0.00005491972,0.01371707],"genre_scores_gemma":[0.1868505,0.004691868,0.001776537,0.07251997,0.2596352,0.00003410924,0.000767798,0.000327144,0.4733969],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.8709332,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005329215029903,"score_gpt":0.3263213178008592,"score_spread":0.2962680256505601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}