{"id":"W2584128250","doi":"10.1038/srep41572","title":"Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; McMaster University","keywords":"Albuminuria; Endocrinology; Internal medicine; Unfolded protein response; Kidney disease; Glomerulosclerosis; Endoplasmic reticulum; Medicine; Renal function; Fibrosis; ATF6; Kidney; Angiotensin II; Proteinuria; Biology; Blood pressure; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191176,0.0003435152,0.0003931936,0.0002111265,0.0001366531,0.0002046349,0.0001876467,0.0002199766,0.001081702],"category_scores_gemma":[0.00009216846,0.00008782401,0.0001974493,0.0001121248,0.0002102789,0.0001936237,0.0001596721,0.0007160747,0.0001808537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001006447,"about_ca_system_score_gemma":0.0001986915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003259914,"about_ca_topic_score_gemma":0.000562741,"domain_scores_codex":[0.999938,0.00001356564,0.000006656815,0.000008983593,0.00001354529,0.00001912512],"domain_scores_gemma":[0.9999033,0.000008016962,0.00003328882,0.000009320082,0.00001416604,0.00003186469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001512178,0.0003942591,0.0002348679,0.00008427679,0.0000224147,0.00004042557,0.00001306756,0.00008442625,0.9921299,0.00009029765,0.00009101308,0.005302808],"study_design_scores_gemma":[0.0003145096,0.005520134,0.01112632,0.00002627735,0.00009515895,0.0001905821,0.00006030981,0.001342685,0.9780014,0.000206397,0.003105668,0.00001061138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951921,0.001577502,0.001998984,0.0001711028,0.00007398516,0.00002588691,0.0001407646,0.0001480276,0.0006717331],"genre_scores_gemma":[0.9928036,0.001805734,0.002497378,0.00009367708,0.0000314399,0.0000392465,0.0002410554,0.0000244877,0.002463423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081702,"threshold_uncertainty_score":0.003618658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009895412910966073,"score_gpt":0.2501311068005608,"score_spread":0.2402356938895947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}