{"id":"W2584272241","doi":"10.1093/neuonc/nov214.06","title":"EPIG-06ATRX DEFICIENCY PROMOTES MIGRATORY BEHAVIOR IN GLIOMA CELLS OF ORIGIN BY DYSREGULATING GENOME-WIDE CHROMATIN ACCESSIBILITY AND MODULATING TRANSCRIPTIONAL PROGRAMS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Chromatin; Epigenetics; Genome instability; Carcinogenesis; Genetics; Cancer research; Cell biology; Gene; Mutation; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004790851,0.0002034895,0.0003180479,0.0000649229,0.00005542945,0.00001544809,0.0001919091,0.0002444963,0.000006027668],"category_scores_gemma":[0.0001208792,0.0002000918,0.0000715694,0.0001738555,0.0002009025,0.00001493307,0.00008400679,0.0001622698,8.358552e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000852018,"about_ca_system_score_gemma":0.0003104772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009571033,"about_ca_topic_score_gemma":0.00007540457,"domain_scores_codex":[0.9981804,0.0002063719,0.0005496304,0.00054569,0.0001990941,0.000318838],"domain_scores_gemma":[0.9992215,0.00004334866,0.0002264407,0.0002583795,0.0001221714,0.0001281496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005931367,0.0003700155,0.04817615,0.00007270822,0.000006174426,0.000006442569,0.0003201648,0.000269346,0.9426662,0.000003999993,0.00006603531,0.007983492],"study_design_scores_gemma":[0.004519009,0.003704604,0.05499627,0.00006104737,0.00009701654,0.0001481346,0.0009372036,0.01488154,0.9163378,0.0001988868,0.003340767,0.0007777315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967843,0.001648464,0.0006494946,0.00004959986,0.0001272356,0.0004833838,0.00002613858,0.00002192894,0.0002094277],"genre_scores_gemma":[0.994528,0.00002720754,0.005083366,0.00007038035,0.00006933693,0.00009338476,0.00009121815,0.00002582959,0.00001127889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02632838,"threshold_uncertainty_score":0.8159506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02991619550471158,"score_gpt":0.2973095869339766,"score_spread":0.267393391429265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}