{"id":"W2584272241","doi":"10.1093/neuonc/nov214.06","title":"EPIG-06ATRX DEFICIENCY PROMOTES MIGRATORY BEHAVIOR IN GLIOMA CELLS OF ORIGIN BY DYSREGULATING GENOME-WIDE CHROMATIN ACCESSIBILITY AND MODULATING TRANSCRIPTIONAL PROGRAMS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"ATRX; Biology; Chromatin; Epigenetics; Genome instability; Carcinogenesis; Genetics; Cancer research; Cell biology; Gene; Mutation; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006759179,0.0002242384,0.000171764,0.0002120612,0.00007128402,0.0001946711,0.0001400587,0.0001513186,0.00148429],"category_scores_gemma":[0.00005019678,0.0001113854,0.000143067,0.0001217659,0.0001545546,0.00008910913,0.0001480856,0.0003556437,0.0003446946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000119451,"about_ca_system_score_gemma":0.0001218582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006774282,"about_ca_topic_score_gemma":0.001376379,"domain_scores_codex":[0.9999171,0.00001051467,0.000007794728,0.0000213802,0.00002238158,0.00002075884],"domain_scores_gemma":[0.9999424,0.000007648365,0.00001508297,0.000008302197,0.00000504878,0.00002150286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008406337,0.00001458297,0.0002651254,0.00001554232,0.000002986581,0.00003739564,0.00001171957,0.00004393783,0.9984307,0.0000442458,0.00003293394,0.001016747],"study_design_scores_gemma":[0.00001314156,0.0003299327,0.02603206,0.000005460672,0.000018573,0.0002658544,0.00006043914,0.001181845,0.9694009,0.00004771573,0.002639089,0.0000049281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960492,0.0005967256,0.00112796,0.00005781713,0.000009119445,0.00001084602,0.0006429835,0.0001140281,0.001391315],"genre_scores_gemma":[0.9940761,0.0004412832,0.001027343,0.00005711133,0.00000326074,0.00002894717,0.0009575259,0.00002841894,0.003379813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148429,"threshold_uncertainty_score":0.004965484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02991619550471158,"score_gpt":0.2973095869339766,"score_spread":0.267393391429265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}