{"id":"W2584365152","doi":"10.1002/pro.3129","title":"Targeting human SET1/MLL family of proteins","year":2017,"lang":"en","type":"review","venue":"Protein Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; University of Ottawa; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Pfizer","keywords":"Methyltransferase; Biology; Computational biology; Genetics; Protein family; Plasma protein binding; Biochemistry; Gene; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485848,0.000267404,0.0005907711,0.0001333158,0.0004098731,0.00009338814,0.00121782,0.0002430855,0.000005836389],"category_scores_gemma":[0.0005751105,0.0002235898,0.0002055119,0.0001971267,0.0006191338,0.000008411778,0.0004625653,0.0001653895,0.00001030346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002580235,"about_ca_system_score_gemma":0.0006836373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004061812,"about_ca_topic_score_gemma":0.00000371991,"domain_scores_codex":[0.9979592,0.00008807899,0.0005209702,0.0006831948,0.0004056912,0.00034287],"domain_scores_gemma":[0.9978712,0.000006227122,0.0008378199,0.0009484595,0.0002371387,0.00009920831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001369902,0.00002700748,0.000006867821,0.002161133,0.00001368155,0.000001476981,0.00001039871,0.000001783578,0.5243387,0.00009392811,0.00001295751,0.4733307],"study_design_scores_gemma":[0.00007310444,0.0001756147,0.00001585169,0.001836808,0.00003764436,8.832708e-7,0.00000359825,0.000003983944,0.06637308,0.0001443818,0.9310278,0.0003072478],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001911642,0.9935675,0.0006536669,0.000003709862,0.0001026554,0.001460121,0.00002701549,0.000007911159,0.002265834],"genre_scores_gemma":[0.005466117,0.9902271,0.003036594,0.000003751181,0.0002387177,0.0002213265,0.0000763758,0.00003473393,0.0006953026],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9310148,"threshold_uncertainty_score":0.9117726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1095717676827518,"score_gpt":0.4117856103980582,"score_spread":0.3022138427153064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}