{"id":"W2584365152","doi":"10.1002/pro.3129","title":"Targeting human SET1/MLL family of proteins","year":2017,"lang":"en","type":"review","venue":"Protein Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; University of Ottawa; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Genome Canada; Pfizer","keywords":"Methyltransferase; Biology; Computational biology; Genetics; Protein family; Plasma protein binding; Biochemistry; Gene; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002084446,0.000613905,0.0005537196,0.001136515,0.0001385957,0.0005113927,0.0006130108,0.0004938706,0.002697032],"category_scores_gemma":[0.000211787,0.0001596866,0.0002486904,0.0007423933,0.0002450377,0.0005528698,0.0005307085,0.001005041,0.003059198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005265845,"about_ca_system_score_gemma":0.0004059596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189298,"about_ca_topic_score_gemma":0.0005852177,"domain_scores_codex":[0.9998877,0.00001037252,0.0000110663,0.0000212121,0.00005464763,0.00001507124],"domain_scores_gemma":[0.9999439,0.00001452947,0.00001392041,0.000003077647,0.00001510435,0.000009398418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006829763,0.00003754893,0.0002950277,0.006145949,0.00007371922,0.0004083462,0.00004085357,0.0003560515,0.04854953,0.004278614,0.02054477,0.9192013],"study_design_scores_gemma":[0.00001190113,0.00005903751,0.0007555944,0.0003791961,0.00004195479,0.002487233,0.00001547211,0.0001087281,0.02001808,0.0007331159,0.975377,0.00001273546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001591394,0.990433,0.001670143,0.000415523,0.0002742892,0.00002517256,0.0001268344,0.00007215915,0.005391565],"genre_scores_gemma":[0.007710115,0.9837404,0.001480405,0.0003547543,0.0001503866,0.00003705556,0.0004442763,0.00001255173,0.006070085],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002697032,"threshold_uncertainty_score":0.009022415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1095717676827518,"score_gpt":0.4117856103980582,"score_spread":0.3022138427153064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}