{"id":"W2584399332","doi":"10.1182/blood.v114.22.3492.3492","title":"Population Pharmacokinetic Model of ADVATE in Pediatric and Adult Patients with Hemophilia A.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Population; Covariate; Pharmacokinetics; Volume of distribution; Mixed model; Internal medicine; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00149889,0.000481258,0.001044242,0.0002827831,0.0001351668,0.0007894484,0.0005229359,0.0005867595,0.002618033],"category_scores_gemma":[0.002695293,0.0003154925,0.0009369008,0.0002736523,0.0002551969,0.000422438,0.0002578953,0.0007908801,0.0005919664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000540464,"about_ca_system_score_gemma":0.0008203107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004999101,"about_ca_topic_score_gemma":0.001963423,"domain_scores_codex":[0.9995358,0.000196151,0.00001670474,0.000136264,0.00006971963,0.00004543926],"domain_scores_gemma":[0.9990552,0.0006346357,0.0001660126,0.00003595957,0.00008524216,0.00002295802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001335389,0.0002252537,0.05131923,0.0002803429,0.0007767433,0.0006571439,0.0003503411,0.8939439,0.005875536,0.00650446,0.003102035,0.03562959],"study_design_scores_gemma":[0.0001249196,0.0007103345,0.02294689,0.00002785731,0.0002752639,0.0004208031,0.00005359082,0.9682499,0.0009868582,0.002177519,0.003984234,0.00004189262],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7163209,0.001835973,0.2665614,0.0007273868,0.00006648701,0.0005105177,0.006709566,0.0006818006,0.006585973],"genre_scores_gemma":[0.9810165,0.0005209892,0.01011073,0.0001157184,0.00002079052,0.0005345448,0.002014326,0.00003956413,0.005626697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004999101,"threshold_uncertainty_score":0.009940028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087253406123685,"score_gpt":0.2660150333549748,"score_spread":0.2551424992937379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}