{"id":"W2584586929","doi":"10.1371/journal.ppat.1006191","title":"Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Alberta Innovates; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Alberta Innovates - Health Solutions; Styrelsen för Internationellt Utvecklingssamarbete; American Liver Foundation","keywords":"Avidity; Repertoire; T-cell receptor; CD8; Immunology; Virology; Biology; Hepatitis C virus; T cell; Cytotoxic T cell; Virus; Memory T cell; Immunity; Immune system; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963621,0.0001530767,0.0002467544,0.0002182213,0.0001232114,0.0002846656,0.00009206357,0.0002269418,0.0007161939],"category_scores_gemma":[0.0003876246,0.0001140258,0.0001187422,0.00009881386,0.0001621421,0.000195745,0.0001916274,0.0002833712,0.0002251829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016188,"about_ca_system_score_gemma":0.0000888417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002343335,"about_ca_topic_score_gemma":0.0002966006,"domain_scores_codex":[0.999856,0.00003094376,0.00001095227,0.00003121908,0.00001854068,0.00005224936],"domain_scores_gemma":[0.9998029,0.00004863244,0.00004834596,0.00003170823,0.0000256994,0.00004267009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000657263,0.00004645299,0.02734098,0.00003239349,0.00001045564,0.0003645864,0.0002859391,0.0001217278,0.9619384,0.00005751056,0.00003645504,0.009107835],"study_design_scores_gemma":[0.00006044189,0.003269947,0.7056435,0.00002148916,0.00007298406,0.006612509,0.0005744639,0.002514986,0.2791276,0.000216466,0.001860862,0.00002477939],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993781,0.0001948384,0.0001987722,0.000006561431,0.000001523865,0.000003959252,0.00001353582,0.000008927113,0.0001937542],"genre_scores_gemma":[0.999552,0.00006838932,0.0001440901,0.00001227494,0.000003189461,0.000004455683,0.00004603464,0.000003805116,0.0001657284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007161939,"threshold_uncertainty_score":0.002395868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916817741211132,"score_gpt":0.2681779024420851,"score_spread":0.2390097250299738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}