{"id":"W2584586929","doi":"10.1371/journal.ppat.1006191","title":"Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Alberta Innovates; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Alberta Innovates - Health Solutions; Styrelsen för Internationellt Utvecklingssamarbete; American Liver Foundation","keywords":"Avidity; Repertoire; T-cell receptor; CD8; Immunology; Virology; Biology; Hepatitis C virus; T cell; Cytotoxic T cell; Virus; Memory T cell; Immunity; Immune system; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979203,0.0001491971,0.000322727,0.0001269777,0.0004595151,0.00003557387,0.00007844398,0.0001343019,0.0001675273],"category_scores_gemma":[0.0004724218,0.0001468061,0.00007167788,0.0000840096,0.0001752515,0.000214476,0.000109838,0.0003007547,0.00006382801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197252,"about_ca_system_score_gemma":0.0001170428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002546821,"about_ca_topic_score_gemma":0.0004838404,"domain_scores_codex":[0.9985707,0.00009520035,0.0002381824,0.0003737851,0.0004580315,0.0002640805],"domain_scores_gemma":[0.9988114,0.00006671319,0.0001733117,0.0004851248,0.0003128601,0.0001505587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003554141,0.0001324593,0.2758901,0.0002502936,0.00004630913,0.00004889293,0.0001519421,0.00001112023,0.7195225,0.00001433305,0.00006793098,0.003508736],"study_design_scores_gemma":[0.0007054441,0.0002006005,0.5776069,0.00008390036,0.00004056199,0.000008942919,0.000006788689,0.0002822353,0.420906,0.00004364428,0.00003326517,0.00008168597],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967548,0.0001214946,0.00009616364,0.00009518189,0.0001575952,0.0003974844,0.00008515635,0.00005213831,0.002239981],"genre_scores_gemma":[0.9976358,0.001154221,0.0003692897,0.00002668605,0.0002518195,0.00003909613,0.00001934641,0.00003246319,0.0004712475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3017168,"threshold_uncertainty_score":0.598658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916817741211132,"score_gpt":0.2681779024420851,"score_spread":0.2390097250299738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}