{"id":"W2584600220","doi":"10.1038/srep41686","title":"Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Cancer Research Society; National Science Foundation","keywords":"Chromatin; Cell biology; Chromatin immunoprecipitation; Chromatin remodeling; Biology; Inflammasome; Flagellin; Epigenetics; Caspase 1; Regulation of gene expression; Molecular biology; Promoter; Gene expression; Genetics; Gene; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002482931,0.0002687392,0.0001619221,0.0001279776,0.0001230764,0.0003137971,0.0001349128,0.0002139579,0.001030658],"category_scores_gemma":[0.0002253951,0.0001058164,0.0002549996,0.000103472,0.0002921562,0.0002618798,0.0002440792,0.0002972846,0.0002114285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202367,"about_ca_system_score_gemma":0.0001209949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009428658,"about_ca_topic_score_gemma":0.0001734545,"domain_scores_codex":[0.9997732,0.00004592055,0.00002123656,0.00007880809,0.0000444502,0.0000363964],"domain_scores_gemma":[0.9998467,0.00001676872,0.00007206048,0.00002497307,0.00002057334,0.00001878022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007945316,0.00001062551,0.0005291924,0.00002086944,0.000004716092,0.00006337144,0.00001432739,0.00004217134,0.9979432,0.0001718384,0.00002877652,0.001091315],"study_design_scores_gemma":[0.00002337624,0.0001908639,0.01818186,0.000008496792,0.00001619325,0.0006525583,0.00004263141,0.0008615676,0.9764555,0.0003440396,0.003215394,0.000007562877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831049,0.003043278,0.01122291,0.0002391451,0.00008913124,0.00002324555,0.0003941444,0.0001026765,0.00178039],"genre_scores_gemma":[0.9956703,0.0006318616,0.002007101,0.00006232978,0.00001773924,0.00001740856,0.0002494545,0.00001090497,0.001332968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030658,"threshold_uncertainty_score":0.00344789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009883400387864207,"score_gpt":0.2418761867246757,"score_spread":0.2319927863368115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}