{"id":"W2584600220","doi":"10.1038/srep41686","title":"Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; University of Toronto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Cancer Research Society; National Science Foundation","keywords":"Chromatin; Cell biology; Chromatin immunoprecipitation; Chromatin remodeling; Biology; Inflammasome; Flagellin; Epigenetics; Caspase 1; Regulation of gene expression; Molecular biology; Promoter; Gene expression; Genetics; Gene; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009149785,0.0001921498,0.0002227081,0.00012467,0.0005887655,0.0002215061,0.0003617045,0.0001812635,0.00004330598],"category_scores_gemma":[0.0005879672,0.0001876262,0.0001471359,0.0001325655,0.0004583078,0.00003480984,0.0002277553,0.00008391481,0.00001342019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001330805,"about_ca_system_score_gemma":0.0001715864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007534461,"about_ca_topic_score_gemma":0.00002736716,"domain_scores_codex":[0.9979832,0.00005153454,0.0005875139,0.0007101307,0.0003298719,0.0003377812],"domain_scores_gemma":[0.9967995,0.000009034787,0.0007932114,0.002114199,0.0001957492,0.0000882998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002083168,0.00006258844,0.02343807,0.00002952357,0.00003375522,0.00001275204,0.00005306314,0.00002583157,0.9568111,0.00001187842,0.01721247,0.002288108],"study_design_scores_gemma":[0.0002084364,0.0000453191,0.03985756,0.00002840987,0.00002264536,0.00001536121,0.00009116754,0.00001302102,0.9151154,0.0009646983,0.04342805,0.0002099579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944071,0.001376728,0.0001178306,0.00005761441,0.001052803,0.0002864634,0.000006201858,0.00001233589,0.002682887],"genre_scores_gemma":[0.9936363,0.00009379959,0.0001621178,0.00001681188,0.00005777348,0.00002301607,0.0003101924,0.00002379734,0.005676237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04169575,"threshold_uncertainty_score":0.7651173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009883400387864207,"score_gpt":0.2418761867246757,"score_spread":0.2319927863368115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}