{"id":"W2584614183","doi":"10.1182/blood.v120.21.178.178","title":"Phase I/II Study of CYT387, a JAK1/JAK2 Inhibitor for the Treatment of Myelofibrosis","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Medicine; Constitutional symptoms; Internal medicine; Gastroenterology; Polycythemia vera; Phases of clinical research; Anemia; Essential thrombocythemia; Surgery; Clinical trial; Bone marrow; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008950607,0.001157569,0.001209514,0.0003475928,0.0003997038,0.0004990496,0.000627177,0.000829758,0.003535154],"category_scores_gemma":[0.0003821846,0.0004096329,0.000407389,0.0002441187,0.000496285,0.0003885299,0.0002018973,0.001994263,0.0007426898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004528619,"about_ca_system_score_gemma":0.001346361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008296121,"about_ca_topic_score_gemma":0.001995298,"domain_scores_codex":[0.9998086,0.00008870797,0.000009592546,0.00002802721,0.00002349841,0.00004164976],"domain_scores_gemma":[0.999648,0.00005213646,0.00004486671,0.00002566424,0.00003227172,0.0001970528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4517558,0.1506173,0.008728055,0.001384743,0.0008724772,0.0007823379,0.0004166951,0.002709063,0.2190602,0.000599616,0.01015147,0.1529222],"study_design_scores_gemma":[0.4522486,0.5130617,0.01396238,0.00005818064,0.0003185251,0.0006591672,0.00005774941,0.001574873,0.01269091,0.0002450595,0.005095245,0.00002762926],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911295,0.001857826,0.0007299245,0.000397159,0.00007931144,0.003101012,0.0007836983,0.000117958,0.001803639],"genre_scores_gemma":[0.9852064,0.002069858,0.002680524,0.000856029,0.0001794516,0.003224216,0.00219833,0.00003617044,0.003549079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003535154,"threshold_uncertainty_score":0.01182628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03913227367097902,"score_gpt":0.327461189414224,"score_spread":0.2883289157432449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}