{"id":"W2584873192","doi":"10.1016/j.bpj.2016.11.2555","title":"State- and Use-Dependent Binding of KCNQ Channel Openers","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Gating; Potassium channel; Stimulation; Biophysics; Pharmacology; Drug; Potassium channel blocker; Mutant; Neuroscience; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008324268,0.0002863901,0.0005724459,0.0003464365,0.0005519494,0.001257048,0.000768777,0.0005395421,0.007624994],"category_scores_gemma":[0.003765879,0.0005104958,0.0004776221,0.000329282,0.0006873423,0.001393728,0.0009341037,0.0007057182,0.0007436139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006150338,"about_ca_system_score_gemma":0.0002906853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00187337,"about_ca_topic_score_gemma":0.003040047,"domain_scores_codex":[0.9990408,0.0001776136,0.00009718225,0.0002005126,0.0002685359,0.0002153312],"domain_scores_gemma":[0.997844,0.001074729,0.0002654562,0.0003312038,0.0002846482,0.00019993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001577511,0.0001559848,0.001974447,0.00007853236,0.00005050928,0.00008878758,0.0003315287,0.0004167508,0.9908289,0.001122741,0.0002797314,0.003094505],"study_design_scores_gemma":[0.00008167753,0.0005209751,0.07769303,0.0000366234,0.0001155336,0.0004982283,0.0004780851,0.01925264,0.897025,0.001180222,0.003002157,0.0001158291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968987,0.0003123297,0.0009729003,0.0000719145,0.0000234277,0.00001621663,0.0001612663,0.00002724989,0.001516064],"genre_scores_gemma":[0.9978353,0.00014172,0.0004254136,0.00004524233,0.00001238014,0.00002231888,0.0003345817,0.00006369187,0.001119292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007624994,"threshold_uncertainty_score":0.02550811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02555738757669843,"score_gpt":0.2733908759963127,"score_spread":0.2478334884196143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}