{"id":"W2584913109","doi":"10.1172/jci89455","title":"Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":321,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Peter MacCallum Cancer Centre","keywords":"Chimeric antigen receptor; Cancer research; Adenosine; T cell; CD8; Antigen; Adenosine A2A receptor; Immunology; Receptor; Chemistry; Medicine; Adenosine receptor; Biology; Pharmacology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005168532,0.0001598,0.0006089759,0.00008647118,0.0004101944,0.0001619226,0.0005647771,0.0001841654,0.001792456],"category_scores_gemma":[0.009536851,0.00009791174,0.00036966,0.0001445002,0.00072909,0.0003339617,0.00008483187,0.001214296,0.0001684785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004984423,"about_ca_system_score_gemma":0.0004561623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001990091,"about_ca_topic_score_gemma":0.000001264067,"domain_scores_codex":[0.9966546,0.000465768,0.001556462,0.0002240208,0.0008261105,0.0002730491],"domain_scores_gemma":[0.9951717,0.001178838,0.002135939,0.0005335212,0.0005753466,0.0004046175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001119647,0.0003588737,0.1174664,0.00005911377,0.0001983025,0.00001602658,0.0004901883,0.00001855441,0.7841672,0.00002577839,0.04830845,0.04777141],"study_design_scores_gemma":[0.006603254,0.002980845,0.3483889,0.0007417554,0.0002139948,0.00004680171,0.0002941885,0.0006097345,0.3909094,0.0005105523,0.2483798,0.0003208673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736769,0.0007489386,0.00008357565,0.02216284,0.001578909,0.0003370822,0.000002024348,0.00001510386,0.001394582],"genre_scores_gemma":[0.9790823,0.003754917,0.005384133,0.001005931,0.006415747,0.000003905968,0.00001254099,0.00003896886,0.004301591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3932578,"threshold_uncertainty_score":0.9991201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147817052941857,"score_gpt":0.4295939475704932,"score_spread":0.3148122422763074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}