{"id":"W2585025605","doi":"10.1182/blood.v114.22.2397.2397","title":"BIK (Bcl2-Interacting Killer) CpG Methylation Status in Multiple Myeloma Patients: a Potential Predictor of Relapsed/Refractory Disease.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"CpG site; DNA methylation; Methylation; Epigenetics; Cancer research; Multiple myeloma; Biology; Bone marrow; Gene silencing; Molecular biology; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000251314,0.0001973387,0.0002324183,0.0005226292,0.0002232341,0.0002563423,0.0001830956,0.0003869396,0.001969726],"category_scores_gemma":[0.0006422615,0.0001320045,0.0001453031,0.0005336722,0.0001328049,0.000169975,0.0001864489,0.000402708,0.0003337322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136054,"about_ca_system_score_gemma":0.0001257457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009553423,"about_ca_topic_score_gemma":0.001031004,"domain_scores_codex":[0.9999095,0.00002105123,0.000009519601,0.00002415326,0.00001899793,0.0000168041],"domain_scores_gemma":[0.9997359,0.00005966393,0.00008619361,0.00001100659,0.00002551798,0.00008175682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008675324,0.00004844354,0.9879318,0.00003275026,0.00003363028,0.0001916758,0.00004834533,0.00007275789,0.004438181,0.00001460705,0.0002119021,0.00610832],"study_design_scores_gemma":[0.00001596707,0.0002746918,0.9972324,0.000007200224,0.00004280249,0.0009253695,0.00006848983,0.0005124075,0.0005274621,0.00003636722,0.0003538401,0.000003186645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983957,0.0007676465,0.0001006586,0.00006745555,0.000005724951,0.000009030626,0.0002968721,0.000008887857,0.0003479501],"genre_scores_gemma":[0.9992823,0.0001298704,0.00009478244,0.00001591894,0.000009713156,0.000006380842,0.0002363516,0.000001629233,0.0002230379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969726,"threshold_uncertainty_score":0.006589413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549118166906418,"score_gpt":0.2760061180421629,"score_spread":0.2605149363730987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}