{"id":"W2585266897","doi":"10.1038/srep41206","title":"Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; University College London; University of Nottingham; National Health and Medical Research Council; European Commission; Université de Sherbrooke","keywords":"Antibiotics; Drug; Staphylococcus aureus; Drug resistance; Bacteria; Microbiology; Antibiotic resistance; Vancomycin; Mode of action; Chemistry; Mechanism of action; Biology; Pharmacology; Biochemistry; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173584,0.00008123123,0.0001106933,0.00001555649,0.0003254749,0.00009445109,0.000114835,0.00007785229,0.0000138165],"category_scores_gemma":[0.0003983591,0.00006720559,0.0000677698,0.00004013721,0.0001723218,0.00001436269,0.00006191366,0.00004158607,0.000001300653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007848303,"about_ca_system_score_gemma":0.00004521893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001033918,"about_ca_topic_score_gemma":0.00002115952,"domain_scores_codex":[0.9991413,0.0000145871,0.0002384173,0.0003772971,0.0001102152,0.0001182228],"domain_scores_gemma":[0.998862,0.00001093901,0.0003637254,0.0004474189,0.0002703672,0.00004558238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003330179,0.00001729348,0.0001801006,0.00001821468,0.00001532088,6.932056e-7,0.00002787223,0.000007495325,0.9983788,0.00001973449,0.0006583036,0.0006428824],"study_design_scores_gemma":[0.0000781881,0.00004696702,0.0005378114,0.00001717707,0.00001010416,0.00001138528,0.000032853,0.0002634866,0.9940521,0.0002486917,0.004619624,0.00008167804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954903,0.00002294967,0.001521963,0.0001493149,0.00244338,0.0002011346,0.00001925256,0.000007213574,0.0001444493],"genre_scores_gemma":[0.9970474,0.000007529202,0.0004933458,0.0000118799,0.00007995743,0.000004021962,0.000423583,0.000006548263,0.001925709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004326754,"threshold_uncertainty_score":0.2740564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764909619282501,"score_gpt":0.3092073791968825,"score_spread":0.2915582830040575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}