{"id":"W2585266897","doi":"10.1038/srep41206","title":"Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; University College London; University of Nottingham; National Health and Medical Research Council; European Commission; Université de Sherbrooke","keywords":"Antibiotics; Drug; Staphylococcus aureus; Drug resistance; Bacteria; Microbiology; Antibiotic resistance; Vancomycin; Mode of action; Chemistry; Mechanism of action; Biology; Pharmacology; Biochemistry; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380017,0.0003197665,0.0003262096,0.000139592,0.0002541537,0.0003473688,0.0003238058,0.0004574567,0.002429817],"category_scores_gemma":[0.0002685658,0.0001753485,0.0002934887,0.00007018242,0.000436046,0.0003877105,0.0004654774,0.00045795,0.0003175342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739474,"about_ca_system_score_gemma":0.0002191155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002755099,"about_ca_topic_score_gemma":0.0003948347,"domain_scores_codex":[0.9998434,0.00002335668,0.00000521726,0.00002588719,0.00005947287,0.0000426254],"domain_scores_gemma":[0.9998792,0.00005681946,0.00002253708,0.000009014458,0.00001632373,0.00001602073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003337092,0.00003429982,0.0002636419,0.00007366524,0.00001222023,0.0001388581,0.00003448961,0.00290861,0.9923206,0.001754517,0.00008484942,0.002340863],"study_design_scores_gemma":[0.00009249491,0.0007037021,0.007288594,0.00001607989,0.00004525985,0.0004854472,0.0001793319,0.2059261,0.7772618,0.004328048,0.003626727,0.00004652138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972507,0.000639461,0.02273921,0.0002626725,0.00005719308,0.00003241042,0.0000320185,0.00007726772,0.003652741],"genre_scores_gemma":[0.9960278,0.00027652,0.002840299,0.00004105935,0.00001099335,0.00002260724,0.00002047714,0.000008990592,0.0007510679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429817,"threshold_uncertainty_score":0.008128524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764909619282501,"score_gpt":0.3092073791968825,"score_spread":0.2915582830040575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}