{"id":"W2585408523","doi":"10.1016/j.bpj.2016.11.2544","title":"Single Molecule Visualization of Topology-Mediated Interactions in Supercoiled DNA","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Near-Field Optical Microscopy","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA supercoil; Magnetic tweezers; DNA; Optical tweezers; Biophysics; DNA origami; Topology (electrical circuits); Molecule; Chemistry; Chemical physics; Nanotechnology; Crystallography; Physics; Materials science; Biology; DNA replication; Optics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382634,0.0001912057,0.0001484139,0.0002625701,0.0003191424,0.0004759489,0.0002888746,0.0003492814,0.001300891],"category_scores_gemma":[0.0002679034,0.0001801044,0.0001091689,0.0001941032,0.0003180823,0.000543855,0.0002691759,0.0006211045,0.0002003555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082599,"about_ca_system_score_gemma":0.0001876523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004929016,"about_ca_topic_score_gemma":0.0007520969,"domain_scores_codex":[0.9999248,0.00001063537,0.000002660001,0.00001844946,0.00002664072,0.00001691426],"domain_scores_gemma":[0.9997154,0.0001049334,0.00005875688,0.00002294121,0.00002485367,0.00007309652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003691716,0.00001320151,0.0001463247,0.00001676285,0.000002716602,0.00003798994,0.00003435222,0.0002531579,0.9981126,0.0003441871,0.00003649789,0.0009653959],"study_design_scores_gemma":[0.00002420966,0.00007231952,0.004583339,0.000007367873,0.000006363441,0.0001598968,0.00009207167,0.01085287,0.9831818,0.0002826549,0.0007256191,0.00001156284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945467,0.0001856846,0.003944742,0.0000728538,0.00001141397,0.000006596746,0.00007327551,0.00004377375,0.001115013],"genre_scores_gemma":[0.993951,0.0001968411,0.00421781,0.00003231804,0.000006682505,0.00001486679,0.0000963011,0.00002337884,0.00146089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300891,"threshold_uncertainty_score":0.004351974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616015092448806,"score_gpt":0.2918173704495082,"score_spread":0.2756572195250201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}