{"id":"W2585821169","doi":"10.1016/j.bpj.2016.11.612","title":"Structural Characterization of Calmodulin Disease Mutations","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Calmodulin; Missense mutation; Phenotype; Sudden death; Biology; Mutant; Genetics; Mutation; Ryanodine receptor 2; Gene; Calcium; Cell biology; Ryanodine receptor; Intracellular; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002172801,0.0005254103,0.0003579591,0.0008108153,0.0003941057,0.0004128493,0.0004831192,0.001145398,0.003476767],"category_scores_gemma":[0.001002548,0.0001333517,0.000514189,0.0003196458,0.0003662954,0.0002700136,0.0002663382,0.0005521796,0.0005760481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997718,"about_ca_system_score_gemma":0.0001925285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202591,"about_ca_topic_score_gemma":0.001034355,"domain_scores_codex":[0.9997395,0.00003444603,0.0000585088,0.00007787447,0.00005884163,0.00003078123],"domain_scores_gemma":[0.9995739,0.0001362464,0.00009403362,0.00003136261,0.00006951726,0.00009496936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006788164,0.0002302591,0.0171731,0.0001116768,0.00007942554,0.01343956,0.0003298914,0.0009918478,0.9547396,0.001111725,0.001023997,0.01009009],"study_design_scores_gemma":[0.0005183081,0.001730596,0.207222,0.0001795886,0.0004220604,0.1072965,0.0005020751,0.02647874,0.6324556,0.001861174,0.02122857,0.0001047769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943404,0.0005795139,0.001952467,0.000336917,0.00009979054,0.00004646985,0.0009090709,0.00005483816,0.001680499],"genre_scores_gemma":[0.9964007,0.0001628638,0.001641467,0.0001764501,0.00003892903,0.00001753723,0.0007210539,0.00003569988,0.0008052128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003476767,"threshold_uncertainty_score":0.01163095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329204208687129,"score_gpt":0.2834047379149229,"score_spread":0.2701126958280516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}