{"id":"W2586053277","doi":"10.1242/bio.021212","title":"Disruption of<i>pdgfra</i>alters endocardial and myocardial fusion during zebrafish cardiac assembly","year":2017,"lang":"en","type":"article","venue":"Biology Open","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; Hospital for Sick Children; National Human Genome Research Institute; University of Toronto; Canada Foundation for Innovation; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"PDGFRA; Endocardium; Zebrafish; Biology; Receptor tyrosine kinase; Heart development; Cell biology; Mutant; Danio; Tyrosine kinase; Somitogenesis; Growth factor receptor; Platelet-derived growth factor receptor; Cancer research; Internal medicine; Kinase; Gene; Genetics; Receptor; Embryonic stem cell; Embryogenesis; Growth factor; Signal transduction; Medicine; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003720645,0.0001414901,0.0002916283,0.00004047768,0.0003430032,0.0001097074,0.0005130876,0.0002012648,0.000009795568],"category_scores_gemma":[0.0002177302,0.0001328957,0.0001230437,0.0000255602,0.0002872677,0.00001838378,0.001704093,0.0001060132,0.00001185548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035987,"about_ca_system_score_gemma":0.00007757953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546381,"about_ca_topic_score_gemma":0.00006682615,"domain_scores_codex":[0.9988307,0.0001796626,0.0001716138,0.0004336784,0.00008777624,0.00029655],"domain_scores_gemma":[0.9990329,0.00002342271,0.00009937055,0.0006646718,0.00007275528,0.0001069531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003166794,0.00001689523,0.1074258,0.00001876626,0.0001011521,0.000003965027,0.00002038458,3.028793e-7,0.88379,0.00006250869,0.0002504237,0.007993207],"study_design_scores_gemma":[0.001439778,0.0006466184,0.6932502,0.00001862665,0.00003646212,0.00002262649,0.00003550033,0.000008074194,0.2838176,0.00006818203,0.02038028,0.0002760444],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937172,0.0004677254,0.00001714371,0.0001285175,0.0004220048,0.0005314673,0.00008212518,0.000006191832,0.004627626],"genre_scores_gemma":[0.9986178,0.0003660077,0.0001038332,0.00002868086,0.0003841387,0.00004475169,0.0000925666,0.00001782902,0.0003443754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5999724,"threshold_uncertainty_score":0.5419331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135309496992998,"score_gpt":0.3355327436543995,"score_spread":0.3141796486844695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}