{"id":"W2586068218","doi":"10.1161/atvb.33.suppl_1.a63","title":"Abstract 63: Post-transcriptional Control of the LDLR Pathway by Cholesterol-responsive microRNAs.","year":2013,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"PCSK9; LDL receptor; microRNA; Cholesterol; Three prime untranslated region; ABCA1; Psychological repression; Biology; Downregulation and upregulation; Untranslated region; Regulator; Cell biology; Receptor; Messenger RNA; Endocrinology; Internal medicine; Gene expression; Medicine; Gene; Biochemistry; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213579,0.0005334624,0.0003193089,0.0002827767,0.0003127228,0.0006311325,0.0001802204,0.0004210161,0.002844615],"category_scores_gemma":[0.0001667849,0.000217813,0.0004969839,0.0001696665,0.0002424644,0.0002757206,0.0003635173,0.0006127178,0.002595881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004235645,"about_ca_system_score_gemma":0.0002710781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004441176,"about_ca_topic_score_gemma":0.000375169,"domain_scores_codex":[0.9997464,0.00003270362,0.00002818596,0.00008757243,0.0000643184,0.00004076693],"domain_scores_gemma":[0.9999189,0.000008410637,0.00002640092,0.00001135819,0.00001915996,0.00001578483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001611601,0.00002443727,0.0002562713,0.0001585042,0.000008569288,0.0002044464,0.0000223874,0.00003775715,0.9863084,0.0009235381,0.0007125856,0.01118186],"study_design_scores_gemma":[0.00004138859,0.0002926008,0.0127494,0.00003945902,0.00004010059,0.001372981,0.00004550154,0.0008942524,0.9436147,0.0006192179,0.04027145,0.00001897331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.6484565,0.161917,0.07293135,0.004475886,0.005940824,0.0006306129,0.006865217,0.00383787,0.09494466],"genre_scores_gemma":[0.9001092,0.02256987,0.01359757,0.001561017,0.0004600248,0.0002678607,0.004529351,0.0002573788,0.05664771],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002844615,"threshold_uncertainty_score":0.00951612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009437212574970046,"score_gpt":0.2228166523708846,"score_spread":0.2133794397959146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}