{"id":"W2586122800","doi":"10.1093/annonc/mdw388.01","title":"Randomized phase 3, multicenter, open-label study comparing evofosfamide (Evo) in combination with doxorubicin (D) vs. D alone in patients (pts) with advanced soft tissue sarcoma (STS): Study TH-CR-406/SARC021","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal General Hospital","funders":"","keywords":"Medicine; Clinical endpoint; Soft tissue sarcoma; Internal medicine; Trabectedin; Chemotherapy; Liposarcoma; Doxorubicin; Sarcoma; Response Evaluation Criteria in Solid Tumors; Progression-free survival; Phases of clinical research; Gastroenterology; Surgery; Oncology; Urology; Randomized controlled trial; Soft tissue; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00161792,0.001926372,0.003032767,0.0004382851,0.000462148,0.00120423,0.001194547,0.001521942,0.008483879],"category_scores_gemma":[0.001418667,0.000807152,0.001710608,0.0005751046,0.001349798,0.001177526,0.000475728,0.003957117,0.001686703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001116831,"about_ca_system_score_gemma":0.001859113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001641534,"about_ca_topic_score_gemma":0.004498993,"domain_scores_codex":[0.9994875,0.0002887141,0.00002277994,0.00009563879,0.00002625253,0.00007916977],"domain_scores_gemma":[0.9989046,0.0002874424,0.0002319965,0.00008748768,0.00005959761,0.0004289866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9784437,0.00714822,0.0004482564,0.0002843638,0.0005053739,0.00002344999,0.0000366468,0.0003314354,0.002429091,0.00009752574,0.000996009,0.009255867],"study_design_scores_gemma":[0.936471,0.06124085,0.0009751291,0.00001755599,0.0002086296,0.00002470925,0.00001822836,0.000262782,0.0001849342,0.0001097196,0.0004764689,0.000009945078],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844344,0.003217337,0.0009556694,0.0009177013,0.0005634182,0.003888739,0.002456162,0.0002245451,0.003342053],"genre_scores_gemma":[0.9787686,0.003088977,0.002727131,0.001919472,0.000513771,0.004980718,0.003276345,0.00007988064,0.004645145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008483879,"threshold_uncertainty_score":0.02838141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07448211169238557,"score_gpt":0.4098059849627034,"score_spread":0.3353238732703178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}