{"id":"W2586123530","doi":"10.1182/blood.v114.22.3078.3078","title":"AT9283, A Novel Aurora Kinase/Jak2 Inhibitor Demonstrates Activity against Refractory Infant Leukemia Cells: Studies On Growth Inhibition, Biological Correlates, Drug Synergy and Effects On Leukemia Stem-Like Cells.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"","keywords":"Leukemia; Stem cell; Cancer research; Cancer stem cell; Cell culture; Growth inhibition; Cell growth; Bone marrow; Stromal cell; Biology; Chemistry; Immunology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649889,0.0004201376,0.0006618769,0.000389849,0.0001858497,0.0002551801,0.0004114094,0.0002967618,0.002494875],"category_scores_gemma":[0.0001104094,0.0001504603,0.0003710031,0.0005187975,0.0001315694,0.0001739772,0.0001598726,0.0006485812,0.001001893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001860275,"about_ca_system_score_gemma":0.0002711968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009849783,"about_ca_topic_score_gemma":0.001666453,"domain_scores_codex":[0.9998747,0.00003615501,0.00001572369,0.00001824261,0.00002810813,0.00002697781],"domain_scores_gemma":[0.9999104,0.00002523669,0.00001248544,0.00001520017,0.00001273979,0.00002387744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001609952,0.000629533,0.0006914825,0.0002580281,0.0000386429,0.0002326939,0.00006666556,0.0003948303,0.9723707,0.0001726222,0.0008883622,0.02264654],"study_design_scores_gemma":[0.0006556447,0.0163013,0.02035192,0.00003287685,0.0001764156,0.002061305,0.00006111797,0.001676112,0.9461968,0.00007113451,0.01238782,0.000027534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685919,0.01668144,0.002398505,0.0002378083,0.00008679071,0.0003115571,0.00220564,0.0003436237,0.009142682],"genre_scores_gemma":[0.981366,0.007735857,0.00275706,0.00009186755,0.00003246705,0.000200808,0.003875718,0.00005189616,0.003888166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002494875,"threshold_uncertainty_score":0.0083462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860582074969928,"score_gpt":0.2157553980443396,"score_spread":0.2071495772946403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}