{"id":"W2586125315","doi":"10.1016/j.ymthe.2017.01.019","title":"Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; American Lebanese Syrian Associated Charities","keywords":"Haematopoiesis; Thalassemia; Gene transfer; Biology; Fusion gene; Globin; Virology; Genetic enhancement; Stem cell; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012738,0.0003604301,0.0001937773,0.0003991355,0.0001300223,0.0002975871,0.0002418634,0.0002881025,0.001673806],"category_scores_gemma":[0.00004565729,0.0001474315,0.0001485849,0.0001522906,0.0002667898,0.0001445059,0.0001616899,0.0007560487,0.0002788563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001753649,"about_ca_system_score_gemma":0.0001943172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008046543,"about_ca_topic_score_gemma":0.001062756,"domain_scores_codex":[0.999912,0.00000762277,0.000009050036,0.00001908003,0.00003130469,0.00002082262],"domain_scores_gemma":[0.9999362,0.000007993299,0.00002180873,0.000006933806,0.0000039037,0.00002305204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005151578,0.00005421612,0.0001144568,0.00001139267,0.000004335224,0.0000573536,0.00001804219,0.00007271377,0.9973985,0.0002136964,0.00007221433,0.001931634],"study_design_scores_gemma":[0.00004828659,0.0002139087,0.001858832,0.00000561251,0.00002587717,0.0002353266,0.0000346522,0.0009622466,0.9928538,0.0000816126,0.003676503,0.000003209761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904186,0.0005629573,0.004726065,0.0001674207,0.00006600038,0.00004799405,0.0004507212,0.0005176738,0.003042593],"genre_scores_gemma":[0.9892032,0.0004431419,0.001926039,0.00006517502,0.00001317867,0.00002376191,0.0003809212,0.00006391905,0.007880708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001673806,"threshold_uncertainty_score":0.005599499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00986730871640047,"score_gpt":0.2338882918678873,"score_spread":0.2240209831514868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}