{"id":"W2586125315","doi":"10.1016/j.ymthe.2017.01.019","title":"Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; American Lebanese Syrian Associated Charities","keywords":"Haematopoiesis; Thalassemia; Gene transfer; Biology; Fusion gene; Globin; Virology; Genetic enhancement; Stem cell; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211701,0.0002401892,0.0004223874,0.00006211999,0.0001549976,0.00004433423,0.0001395127,0.0001591705,0.00004666181],"category_scores_gemma":[0.000002239997,0.0001663428,0.000107742,0.00008568513,0.0002302563,0.00007260907,0.00003094674,0.0001767642,0.000007249095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478259,"about_ca_system_score_gemma":0.0000504638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004371667,"about_ca_topic_score_gemma":0.000002698134,"domain_scores_codex":[0.9988608,0.00004240852,0.0002436845,0.0003133141,0.0002761901,0.0002636066],"domain_scores_gemma":[0.9991187,0.00001061233,0.00008576094,0.000583431,0.00007817284,0.0001233264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006109293,0.0002444281,0.005434986,0.0001128335,0.0001753415,0.0002521232,0.0007631667,0.00001177275,0.9817913,0.00006954349,0.00004486538,0.01048869],"study_design_scores_gemma":[0.00578464,0.001059458,0.00438081,0.0002508018,0.00009111111,0.00008377752,0.0003034029,0.00007861212,0.9869177,0.00005578368,0.0007785059,0.0002153415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931051,0.004120241,0.0009477084,0.0005489215,0.00007010708,0.0004804531,0.00000743283,0.00003475767,0.0006852462],"genre_scores_gemma":[0.9959723,0.003166795,0.0002164673,0.0001755764,0.00001917498,0.00001511298,0.000008274627,0.00004790759,0.0003784152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01027334,"threshold_uncertainty_score":0.6783264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00986730871640047,"score_gpt":0.2338882918678873,"score_spread":0.2240209831514868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}