{"id":"W2586129086","doi":"10.1182/blood.v116.21.499.499","title":"Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University Health Network","funders":"","keywords":"Nod; Homing (biology); CD47; Severe combined immunodeficiency; Haematopoiesis; Innate immune system; Immunology; Cancer research; Immune system; Bone marrow; Leukemia; Biology; Stem cell; Myeloid; NOD mice; Cell biology; In vivo; Autoimmunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591978,0.0002956652,0.0002358914,0.0001353532,0.00008813181,0.0002811548,0.0001571957,0.000179708,0.000760588],"category_scores_gemma":[0.0000496476,0.000100951,0.0001916174,0.00008857354,0.0002106895,0.0001011162,0.0002127723,0.0003528547,0.0004477531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001808694,"about_ca_system_score_gemma":0.0001245489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002048088,"about_ca_topic_score_gemma":0.0003714881,"domain_scores_codex":[0.9998841,0.00001997526,0.00001330282,0.00002060109,0.00003646392,0.00002548368],"domain_scores_gemma":[0.9999279,0.00001005344,0.00003156796,0.000008197127,0.000006596873,0.00001570762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005656673,0.000006789052,0.0002418083,0.00001688341,0.00000217182,0.00001635513,0.000005461164,0.00001761084,0.9992305,0.00003916058,0.00001113648,0.0003555617],"study_design_scores_gemma":[0.00001355884,0.0001444171,0.003736542,0.000005382966,0.00001040861,0.0001589286,0.00001918279,0.0004575772,0.9941784,0.00002013791,0.001253907,0.000001558331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945104,0.001226992,0.002995667,0.00008321942,0.000007376204,0.00002854446,0.0002809017,0.00005344905,0.0008134439],"genre_scores_gemma":[0.9955876,0.0005698468,0.001968458,0.00004961564,0.000006135616,0.00004619661,0.0004555172,0.000009481772,0.001307032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000760588,"threshold_uncertainty_score":0.002544403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004714687825561547,"score_gpt":0.2166258301721784,"score_spread":0.2119111423466169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}