{"id":"W2586148767","doi":"10.21769/bioprotoc.2117","title":"Heterochronic Pellet Assay to Test Cell-cell Communication in the Mouse Retina","year":2017,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Ottawa; Alberta Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Retina; Cell biology; Retinal; Heterochrony; Cell type; Cell; Cell fate determination; Progenitor cell; Molecular biology; Stem cell; Genetics; Neuroscience; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008573732,0.001650744,0.0005567956,0.002386673,0.0008759496,0.0006185324,0.0009872998,0.001258293,0.009051492],"category_scores_gemma":[0.0003509198,0.0009150055,0.0008985983,0.0007687873,0.0004838468,0.0006963272,0.0007710647,0.00301369,0.005597129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005978454,"about_ca_system_score_gemma":0.0006265951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102001,"about_ca_topic_score_gemma":0.004066817,"domain_scores_codex":[0.9989892,0.0001441178,0.0001366737,0.00027536,0.0003425313,0.00011214],"domain_scores_gemma":[0.9992473,0.0001436632,0.0001514052,0.0001759414,0.0001396675,0.0001421033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006334867,0.0000639204,0.000180425,0.00007033075,0.00001355687,0.00004995518,0.00003036585,0.00002838228,0.9964057,0.000639979,0.0003222967,0.002131799],"study_design_scores_gemma":[0.00003126657,0.000314616,0.00427238,0.00003528413,0.0000557414,0.0002730167,0.00002563362,0.0007082373,0.986155,0.000226506,0.007889653,0.00001269277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4127435,0.01058858,0.5045871,0.0007409543,0.001222251,0.002546937,0.01344619,0.005209907,0.04891458],"genre_scores_gemma":[0.4810663,0.007346855,0.3349699,0.000876273,0.000240795,0.008641151,0.02047019,0.002088287,0.1443002],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.009051492,"threshold_uncertainty_score":0.03028029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508294198558222,"score_gpt":0.303424366391797,"score_spread":0.2883414244062147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}