{"id":"W2586187189","doi":"10.1093/annonc/mdw370.03","title":"A randomized phase III study of napabucasin [BBI608] (NAPA) vs placebo (PBO) in patients (pts) with pretreated advanced colorectal cancer (ACRC): the CCTG/AGITG CO.23 trial","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; University of Alberta; University of Toronto; Vancouver General Hospital; Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"","keywords":"NAPA; Medicine; Internal medicine; Gastroenterology; Placebo; Nausea; Clinical endpoint; Phases of clinical research; Cancer; Progression-free survival; Randomized controlled trial; Clinical trial; Overall survival; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009036177,0.001611975,0.002591534,0.000308586,0.0003465877,0.000914202,0.0007051391,0.001499144,0.00718583],"category_scores_gemma":[0.001123331,0.0005130366,0.001270952,0.0003833574,0.0009254541,0.0007537869,0.0003653557,0.003061612,0.001550138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006718074,"about_ca_system_score_gemma":0.001039596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436436,"about_ca_topic_score_gemma":0.003729048,"domain_scores_codex":[0.9997017,0.0001513244,0.00001085845,0.00005638169,0.00001965758,0.00006008465],"domain_scores_gemma":[0.9994192,0.0001288589,0.0001067767,0.00004511562,0.00003474459,0.0002653135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9783499,0.003316856,0.0003836353,0.0003567202,0.0005542403,0.00003129309,0.00002632565,0.0002274866,0.00307022,0.000110735,0.001204929,0.01236771],"study_design_scores_gemma":[0.9632864,0.03391644,0.001178968,0.00002225581,0.0002888493,0.00002809299,0.00001564146,0.0002303512,0.0002096529,0.0001313607,0.0006825656,0.00000947039],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781203,0.007693416,0.0007673319,0.001465325,0.001033867,0.003854142,0.002442581,0.0002346337,0.004388392],"genre_scores_gemma":[0.9822348,0.004140711,0.001272607,0.00167551,0.0005075084,0.003098462,0.002214318,0.00004844635,0.004807754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00718583,"threshold_uncertainty_score":0.02403897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1505263278603289,"score_gpt":0.4931195601141561,"score_spread":0.3425932322538272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}