{"id":"W2586189029","doi":"10.1016/j.cellsig.2017.02.009","title":"Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling","year":2017,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; University of Sydney; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Jain Foundation","keywords":"Dysferlin; Cleavage factor; Cleavage (geology); C2 domain; Cleavage stimulation factor; Endocytosis; Cell biology; Exon; Biology; Chemistry; Biochemistry; Membrane; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000496022,0.0002113116,0.0002562979,0.00008409897,0.0004053337,0.00008105524,0.0002864688,0.0002108438,0.00005171879],"category_scores_gemma":[0.0002440225,0.0002110386,0.0001941329,0.00006427649,0.0001048345,0.00001082887,0.0001470982,0.0001281157,0.00003461388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001957527,"about_ca_system_score_gemma":0.00006862244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002354907,"about_ca_topic_score_gemma":0.00001085782,"domain_scores_codex":[0.9985064,0.00009836185,0.0004214274,0.0004335032,0.0002550521,0.0002852328],"domain_scores_gemma":[0.9987837,0.00002699065,0.0002960229,0.0005895802,0.0001332635,0.0001704569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001599193,0.00007592718,0.0002038549,0.0000737288,0.00006186929,0.00001140431,0.0001252453,0.002607863,0.9948522,0.0001622769,0.000428944,0.001236735],"study_design_scores_gemma":[0.0006757161,0.0002779258,0.0005093061,0.0001552786,0.00004011017,0.000005346029,0.0001355121,0.003871921,0.9894429,0.0004394636,0.004143655,0.000302851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8117865,0.0005821614,0.1864829,0.0001321758,0.0002068619,0.0003740145,0.000008642816,0.00002296348,0.0004038053],"genre_scores_gemma":[0.9931706,0.00003015797,0.005037043,0.0001174802,0.000515165,0.00002787026,0.00009673068,0.00004257852,0.0009623927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1814458,"threshold_uncertainty_score":0.8605903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578726942394929,"score_gpt":0.2404999850154763,"score_spread":0.224712715591527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}