{"id":"W2586230787","doi":"10.1016/j.bmcl.2017.02.007","title":"Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Streptomyces; Tripeptide; Moiety; Stereochemistry; Thiostrepton; In vitro; Streptomycetaceae; Cathepsin D; Biochemistry; Pepstatin; Cathepsin L; Cathepsin; Actinomycetales; Molecular biology; Enzyme; Peptide; Gene; Protease; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006113616,0.0002831063,0.0001693208,0.0001063661,0.00006440338,0.0001689705,0.0001107033,0.0001843952,0.0007160689],"category_scores_gemma":[0.00009683742,0.00008048259,0.0001285529,0.00008522582,0.0001332855,0.0001296674,0.0001264919,0.0003224961,0.0002992569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020956,"about_ca_system_score_gemma":0.000116548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002066507,"about_ca_topic_score_gemma":0.0002978338,"domain_scores_codex":[0.9999454,0.00001222203,0.000005770284,0.000009720008,0.00001469518,0.00001229324],"domain_scores_gemma":[0.9999466,0.00001251897,0.00001608061,0.000005442972,0.000004805779,0.00001461989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009811062,0.000006849385,0.00006318871,0.00001634207,0.000002597889,0.00005301082,0.000002917639,0.00004974892,0.9987487,0.00001491739,0.00001130846,0.0009323846],"study_design_scores_gemma":[0.00001853845,0.0003113677,0.00102649,0.000002208656,0.000008261788,0.0003693375,0.000007456284,0.0002175377,0.9970589,0.00001570726,0.0009616092,0.000002674731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932352,0.001604477,0.003203815,0.00007568509,0.00002989243,0.00002431586,0.0002450049,0.0000464701,0.001535154],"genre_scores_gemma":[0.9962438,0.0006799823,0.001462376,0.00002683006,0.000008374404,0.000006949421,0.0002874115,0.000009706404,0.001274429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007160689,"threshold_uncertainty_score":0.002395451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107351526559597,"score_gpt":0.2400881021300468,"score_spread":0.2293529494740871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}