{"id":"W2586251854","doi":"10.1182/blood.v118.21.4328.4328","title":"Should Generic Versions of Low Molecular Weight Heparins Be Considered As Generic or Biosimilar Drugs. A Regulatory Dilemma","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biosimilar; Medicine; Pharmacology; Pharmacodynamics; Clinical trial; Low molecular weight heparin; Discovery and development of direct thrombin inhibitors; Heparin; Pharmacokinetics; Thrombin; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1716728,0.0008930192,0.002872962,0.002444931,0.005043404,0.01518948,0.005684721,0.05667223,0.006183761],"category_scores_gemma":[0.2341654,0.001199648,0.002277799,0.002179581,0.02144928,0.02332462,0.004694128,0.03238429,0.006220276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005338083,"about_ca_system_score_gemma":0.01521781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004986044,"about_ca_topic_score_gemma":0.004230621,"domain_scores_codex":[0.90279,0.03404407,0.01136725,0.01172683,0.03541876,0.004653088],"domain_scores_gemma":[0.7694305,0.1293152,0.01360299,0.01439307,0.05894279,0.0143153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003959339,0.0003950334,0.001768159,0.0008572139,0.0001200316,0.0008131122,0.001852994,0.0004068061,0.002449721,0.2849459,0.5035648,0.2024302],"study_design_scores_gemma":[0.0004308689,0.0004954514,0.001984346,0.002898766,0.0001053679,0.001645133,0.002058979,0.001139439,0.001661508,0.1559466,0.8313153,0.0003181925],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002425744,0.01391738,0.002672534,0.9594622,0.0100463,0.00009189172,0.00006591136,0.0001001162,0.01121791],"genre_scores_gemma":[0.05305198,0.01077245,0.01147581,0.8973949,0.01829538,0.0002250752,0.0001312726,0.0002394075,0.008413685],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1716728,"threshold_uncertainty_score":0.9079032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504492835119005,"score_gpt":0.2621472131924217,"score_spread":0.2116979296805212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}