{"id":"W2586275027","doi":"10.1182/blood.v126.23.3806.3806","title":"AGS62P1, a Novel Anti-FLT3 Antibody Drug Conjugate, Employing Site Specific Conjugation, Demonstrates Preclinical Anti-Tumor Efficacy in AML Tumor and Patient Derived Xenografts","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Tyrosine kinase; Cancer research; Cytotoxic T cell; Monoclonal antibody; Receptor tyrosine kinase; Antibody-drug conjugate; Antibody; Biology; Medicine; In vitro; Immunology; Receptor; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785719,0.0002852108,0.0002204854,0.000158007,0.0001066015,0.0001983801,0.0001702019,0.0003033651,0.0007081673],"category_scores_gemma":[0.000121299,0.0001022023,0.0001099301,0.0001121872,0.000159563,0.0001775084,0.0001063308,0.0005078454,0.0001522456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428651,"about_ca_system_score_gemma":0.0001731945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00064705,"about_ca_topic_score_gemma":0.000728554,"domain_scores_codex":[0.9999201,0.00001752413,0.00000503773,0.00001537074,0.00002558263,0.00001638207],"domain_scores_gemma":[0.9999436,0.00001412765,0.00001279521,0.000006299282,0.000007872653,0.00001538781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003233664,0.0004934586,0.0002730289,0.00006390044,0.00001035755,0.00007114333,0.0000309476,0.0009325045,0.9897171,0.0001651556,0.0002017633,0.007717125],"study_design_scores_gemma":[0.0001039386,0.003932417,0.00166838,0.000003341575,0.00001381528,0.0002383018,0.000006306097,0.003004947,0.9894133,0.00002283971,0.001588627,0.000003741827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953348,0.0008228565,0.002266804,0.00006462618,0.00001942405,0.00006733717,0.0001672574,0.00009906168,0.001157825],"genre_scores_gemma":[0.9969631,0.0004245876,0.001268903,0.00002430363,0.000006368874,0.00003021683,0.0002727588,0.000008478686,0.001001165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007081673,"threshold_uncertainty_score":0.002369046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04749170708988579,"score_gpt":0.3286951115545997,"score_spread":0.2812034044647139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}