{"id":"W2586281078","doi":"10.1182/blood.v126.23.3858.3858","title":"Myeloid-Related Protein S100A9 Induces Cellular Differentiation in Acute Myeloid Leukemia through TLR2 and TLR4 Receptors","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"S100A8; S100A9; Myeloid leukemia; Myeloid; Leukemia; Immunology; TLR2; Integrin alpha M; Biology; CD33; Calprotectin; Receptor; Cancer research; Population; Molecular biology; Medicine; Flow cytometry; CD34; Inflammation; TLR4; Internal medicine; Cell biology; Stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286276,0.0003366051,0.0002197054,0.0003344408,0.0001172581,0.0002308313,0.0001321977,0.0003299982,0.002399676],"category_scores_gemma":[0.00008979742,0.000166689,0.0003490264,0.0001535788,0.0002559176,0.0001859862,0.0002977063,0.0009972526,0.0006546623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892265,"about_ca_system_score_gemma":0.0001237387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003253757,"about_ca_topic_score_gemma":0.000530138,"domain_scores_codex":[0.9997442,0.00005290015,0.00002560435,0.0000332151,0.00006587656,0.00007812523],"domain_scores_gemma":[0.9998964,0.00000986196,0.00003410291,0.0000101486,0.00001040802,0.00003914791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002162382,0.00005042302,0.0003563941,0.00003617009,0.000004234343,0.00006159709,0.0000101526,0.00002797715,0.9983504,0.00007964439,0.00004946388,0.0007572494],"study_design_scores_gemma":[0.000113291,0.001160597,0.02574778,0.00002239683,0.00003962699,0.0007559001,0.0001572882,0.002431626,0.9639124,0.00018597,0.005465181,0.000007910267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954948,0.0009897142,0.001483659,0.0001668495,0.00003485695,0.00004121489,0.0003978323,0.00007493363,0.001315982],"genre_scores_gemma":[0.9937034,0.0005255186,0.001388135,0.00009268129,0.00001060877,0.00007053114,0.0005335096,0.00001067833,0.003664817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002399676,"threshold_uncertainty_score":0.008027732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200892663381782,"score_gpt":0.2236148266899953,"score_spread":0.2116059000561775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}