{"id":"W2586288138","doi":"10.1182/blood.v120.21.3003.3003","title":"PI3K-Independent Signaling Pathways Contribute to ICOS-Mediated T-Cell Costimulation in Acute Graft-Versus-Host Disease in Mice.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"T cell; CD8; Cytotoxic T cell; T-cell receptor; PI3K/AKT/mTOR pathway; Immunology; CD28; Biology; Cell biology; Immune system; Chemistry; Signal transduction; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002732232,0.001214648,0.0004076161,0.0006770665,0.0002337247,0.00051259,0.0003418167,0.0007255895,0.001295308],"category_scores_gemma":[0.0001390512,0.0003743321,0.0005999586,0.0002508541,0.000487835,0.0006404778,0.0002589256,0.001922278,0.0005136332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385252,"about_ca_system_score_gemma":0.000281258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003365749,"about_ca_topic_score_gemma":0.0004777983,"domain_scores_codex":[0.9997047,0.00004632474,0.00002901409,0.00005176042,0.00006428333,0.0001039766],"domain_scores_gemma":[0.9996536,0.00002145546,0.0001669775,0.00002477711,0.00001707858,0.0001162376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005116063,0.0001011152,0.0003071503,0.00006784505,0.000005941213,0.00009996381,0.00001640265,0.0000909296,0.9976574,0.0001614984,0.00005314195,0.0009269221],"study_design_scores_gemma":[0.0002215432,0.001606196,0.01194522,0.00003976022,0.00009491576,0.0008568929,0.00008560708,0.003077592,0.9793098,0.0002354555,0.002513421,0.00001351056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910533,0.002682243,0.003247794,0.0002281976,0.00007425987,0.00007994488,0.0005742537,0.0001476994,0.001912282],"genre_scores_gemma":[0.9932302,0.001361429,0.002339086,0.00009993193,0.000045405,0.000122581,0.0004671891,0.00004579063,0.002288457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295308,"threshold_uncertainty_score":0.004333198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324585021107558,"score_gpt":0.2236453244919413,"score_spread":0.2103994742808658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}