{"id":"W2586313031","doi":"10.1182/blood.v126.23.3983.3983","title":"Updated Results of a Phase I Study of Ibrutinib and Lenalidomide in Patients with Relapsed and Refractory B-Cell Non-Hodgkin's Lymphoma","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Lenalidomide; Medicine; Ibrutinib; Mantle cell lymphoma; Neutropenia; Internal medicine; Febrile neutropenia; Gastroenterology; Rituximab; Tumor lysis syndrome; Lymphoma; Oncology; Multiple myeloma; Toxicity; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005326393,0.0001520299,0.0004789299,0.0002080865,0.00001562088,0.000006813708,0.00008329218,0.00008692576,0.000003469426],"category_scores_gemma":[0.0002673654,0.0001150605,0.00001705982,0.000306072,0.0001501873,0.00007895254,0.0001051592,0.0001069446,0.000001331576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004555422,"about_ca_system_score_gemma":0.00176777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293039,"about_ca_topic_score_gemma":0.00007182847,"domain_scores_codex":[0.998274,0.000103251,0.0004929971,0.0003330138,0.0005631688,0.000233577],"domain_scores_gemma":[0.9987654,0.000122244,0.0002095007,0.0004323813,0.0002578011,0.0002126872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1992011,0.1909215,0.5461141,0.001442025,0.001212928,0.001527201,0.03432756,0.00001620105,0.01048665,0.000006876915,0.002432897,0.01231085],"study_design_scores_gemma":[0.8960571,0.0160339,0.07458335,0.0002378549,0.0002487084,0.00002633018,0.001568172,0.0002543226,0.01072104,0.000004528322,0.000117453,0.0001472564],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979607,0.0001552477,6.282124e-7,0.00001546212,0.00001686779,0.0009594588,0.00002747873,0.00001122877,0.0008529171],"genre_scores_gemma":[0.9995885,0.00001528671,0.00018194,0.00001335714,0.00001584913,0.00001175605,0.00003800467,0.00002370428,0.0001115664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.696856,"threshold_uncertainty_score":0.469203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712260056935359,"score_gpt":0.284229050499581,"score_spread":0.2671064499302274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}