{"id":"W2586341484","doi":"10.1021/acs.orglett.6b03619","title":"Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics","year":2017,"lang":"en","type":"article","venue":"Organic Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Institute of Infection and Immunity; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"Antibiotics; Chemistry; Stereochemistry; Substituent; Micromonospora; Microbiology; Bacteria; Biology; Biochemistry; Streptomyces; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009812466,0.0003956504,0.0002196529,0.0001632245,0.0001112096,0.0002249817,0.0001315879,0.0002392987,0.0005665813],"category_scores_gemma":[0.0001362361,0.0001153707,0.000138407,0.0001389308,0.0001360166,0.000175138,0.0002163402,0.0003207946,0.0002442985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009680123,"about_ca_system_score_gemma":0.0001824134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005858595,"about_ca_topic_score_gemma":0.001261256,"domain_scores_codex":[0.999882,0.00001829292,0.00001315952,0.00001933599,0.00004068265,0.00002666007],"domain_scores_gemma":[0.9999146,0.00001366857,0.00001647702,0.00001015821,0.00001414226,0.00003089371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004608794,0.00001184766,0.0003162626,0.00001180218,0.000002103679,0.00005188181,0.00001160162,0.00002680089,0.9984187,0.00001801755,0.00001186301,0.001073058],"study_design_scores_gemma":[0.00001076739,0.0003453695,0.007432273,0.000006019541,0.00001313889,0.0001886813,0.00005043071,0.0002109894,0.9899635,0.00003016489,0.001744846,0.000003931758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960867,0.0008862187,0.001029201,0.00005088875,0.00001810595,0.00001891534,0.0002750522,0.00002060548,0.001614349],"genre_scores_gemma":[0.9938367,0.0008279808,0.002202758,0.00002339564,0.00001656329,0.00002276719,0.0007205259,0.00001064871,0.002338714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005858595,"threshold_uncertainty_score":0.001895368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00452388083895438,"score_gpt":0.2012941228789672,"score_spread":0.1967702420400128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}