{"id":"W2586349952","doi":"10.1182/blood.v104.11.1968.1968","title":"The Leukemogenic Potential of the NUP98-PMX1 Fusion Protein Is Independent of the Known Binding Properties of PMX1 to the Serum Response Factor and the Serum Response Element and Requires the NUP98 Sequences.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Biology; Hox gene; Homeobox; Haematopoiesis; Fusion gene; Fusion protein; Molecular biology; Serum Response Element; Cancer research; Green fluorescent protein; Transplantation; Reporter gene; Gene; Stem cell; Cell biology; Serum response factor; Genetics; Transcription factor; Gene expression; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738079,0.0003513982,0.000178221,0.0001670058,0.0001855414,0.000272214,0.0001785762,0.0003143948,0.001759899],"category_scores_gemma":[0.0001129501,0.0001041698,0.0002160473,0.0001267098,0.0003360893,0.0002106955,0.0003225736,0.000663439,0.000456555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318568,"about_ca_system_score_gemma":0.0001294481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699554,"about_ca_topic_score_gemma":0.0002261785,"domain_scores_codex":[0.9998709,0.00002257131,0.00001004109,0.00003120736,0.00003679357,0.00002840734],"domain_scores_gemma":[0.9998692,0.00002862491,0.00003146449,0.00002222619,0.000007393649,0.00004109062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004302666,0.00001342689,0.00007632293,0.0000142094,0.000001993181,0.00002418182,0.000007494703,0.00002184802,0.999191,0.0001121638,0.00002286982,0.0004713957],"study_design_scores_gemma":[0.00001443714,0.0002182135,0.002733306,0.000004499439,0.000007985061,0.0004524896,0.0000130065,0.0006159001,0.9926513,0.0000647605,0.003221531,0.000002559047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929416,0.001250676,0.004119199,0.0001184906,0.0000305617,0.0000298037,0.0003248534,0.0001122842,0.001072701],"genre_scores_gemma":[0.9943341,0.0003572536,0.001708454,0.00002739702,0.000006798247,0.00002970015,0.001008053,0.00002116409,0.002507064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759899,"threshold_uncertainty_score":0.005887389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391004035657501,"score_gpt":0.2495209657732575,"score_spread":0.2356109254166825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}