{"id":"W2586431064","doi":"10.1084/jem.20160446","title":"Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Child Health and Human Development; Nancy Lurie Marks Family Foundation; Boston Children's Hospital; U.S. Department of Defense","keywords":"CTGF; Oligodendrocyte; TSC1; Biology; TSC2; PI3K/AKT/mTOR pathway; Myelin; Neuroscience; Tuberous sclerosis; Phenotype; Cell biology; Growth factor; Signal transduction; Genetics; Central nervous system; Medicine; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043418,0.0008336508,0.0003028801,0.001400218,0.000412976,0.0003895547,0.0004144372,0.0007493411,0.001855693],"category_scores_gemma":[0.0001978355,0.0002897252,0.0002962711,0.0003608099,0.0009202114,0.0002837578,0.0003007161,0.001205447,0.0004224996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001005095,"about_ca_system_score_gemma":0.0006241032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00350982,"about_ca_topic_score_gemma":0.005852207,"domain_scores_codex":[0.9996129,0.00006102199,0.00003439401,0.00008094153,0.000145511,0.00006526861],"domain_scores_gemma":[0.9996449,0.00003413077,0.0001099895,0.00003016451,0.0000284072,0.0001524339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002348032,0.00007166641,0.0001977701,0.00003092223,0.000008323424,0.0002282601,0.00002877148,0.0001068733,0.9979091,0.0002633034,0.0001206386,0.0007996064],"study_design_scores_gemma":[0.0001442904,0.0006838501,0.007271397,0.00004524201,0.0000520374,0.002344704,0.0001151917,0.004120317,0.979509,0.0003444847,0.005348161,0.00002126384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922209,0.001248184,0.002503736,0.0004085131,0.00007026015,0.00005449369,0.0008339053,0.0002728694,0.002387077],"genre_scores_gemma":[0.98705,0.0009249419,0.003925842,0.0001161322,0.00001813049,0.000181476,0.0006645557,0.00009298208,0.00702608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00350982,"threshold_uncertainty_score":0.007292509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034014632875497,"score_gpt":0.3575669702166144,"score_spread":0.2541655069290647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}