{"id":"W2586441381","doi":"10.1016/j.toxlet.2017.02.005","title":"Prenatal melamine exposure impairs spatial cognition and hippocampal synaptic plasticity by presynaptic and postsynaptic inhibition of glutamatergic transmission in adolescent offspring","year":2017,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Melamine detection and toxicity","field":"Agricultural and Biological Sciences","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Long-term potentiation; Excitatory postsynaptic potential; Neuroscience; Morris water navigation task; Synaptic plasticity; Hippocampal formation; Hippocampus; Glutamatergic; Postsynaptic potential; Glutamate receptor; Neurotransmission; Psychology; Chemistry; Medicine; Internal medicine; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847363,0.0001720157,0.0002657206,0.00003494579,0.0002196893,0.00004437822,0.0001015482,0.0001738946,0.00007163392],"category_scores_gemma":[0.00008950997,0.00009261697,0.00003893505,0.00004550175,0.000296948,0.0001701138,0.00007546715,0.0001993945,0.00000196325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002667544,"about_ca_system_score_gemma":0.000004201714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001962337,"about_ca_topic_score_gemma":0.0004176522,"domain_scores_codex":[0.9988418,0.0001305851,0.0002997504,0.0003341241,0.0001292895,0.0002644245],"domain_scores_gemma":[0.9994884,0.0001364617,0.0001921604,0.000057765,0.00002054107,0.0001047085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002366712,0.0001261001,0.01332999,0.00007681948,0.0000202938,0.00002166394,0.00007090742,0.000005235629,0.9729531,0.000007405448,0.00001378553,0.01313802],"study_design_scores_gemma":[0.001235622,0.0009348025,0.8156078,0.0001939748,0.00004595902,0.0000506352,0.00005849873,0.002443823,0.1791373,0.00006111441,0.00001544257,0.0002150433],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974941,0.00007666183,0.0001133341,0.001824537,0.00009228886,0.0003173559,0.00003566508,0.00003029334,0.00001577406],"genre_scores_gemma":[0.9996102,0.00003926277,0.00003039375,0.0002208254,0.00005301132,0.0000167065,0.00002328188,0.000001981102,0.00000427582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8022778,"threshold_uncertainty_score":0.377681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124427041985547,"score_gpt":0.2120433940744463,"score_spread":0.2007991236545908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}