{"id":"W2586457484","doi":"10.1182/blood.v120.21.770.770","title":"Mutated IDH1 Has 2-Hydroxyglutarate-Independent Functions in Leukemogenesis","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"IDH1; Biology; Cancer research; CTL*; Bone marrow; Molecular biology; Mutation; Immunology; CD8; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004273,0.000271832,0.0001219132,0.0002132201,0.00009370702,0.0001705703,0.000135426,0.0001881993,0.001225444],"category_scores_gemma":[0.0000518737,0.00008910319,0.0001285249,0.0001090536,0.000167269,0.00008676732,0.0001370498,0.0002499541,0.0003425288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959743,"about_ca_system_score_gemma":0.0001084377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004863356,"about_ca_topic_score_gemma":0.0005436451,"domain_scores_codex":[0.999921,0.0000117214,0.000006925115,0.00001564433,0.00002602047,0.00001881284],"domain_scores_gemma":[0.9999357,0.00001181152,0.00001603332,0.000006503649,0.000005707594,0.00002409068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006988657,0.00001232151,0.0005004039,0.000009811579,0.000002285449,0.00003858057,0.000004791779,0.00003256651,0.9986552,0.00007604572,0.0000180493,0.0005800996],"study_design_scores_gemma":[0.0000118693,0.0001470288,0.009589317,0.00000345933,0.000009603589,0.0004786764,0.00001776242,0.0008766378,0.9873847,0.00006378123,0.001414544,0.000002632031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969305,0.0006623439,0.00113534,0.00005065469,0.0000137729,0.000008445082,0.0002404547,0.0000316509,0.0009267721],"genre_scores_gemma":[0.997143,0.0002217473,0.0008401438,0.00001958101,0.000004541821,0.000007244636,0.0004491953,0.000008614073,0.001305895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225444,"threshold_uncertainty_score":0.004099488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827588053739694,"score_gpt":0.2405243063327986,"score_spread":0.2222484257954017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}