{"id":"W2586527205","doi":"10.1200/jco.2013.31.15_suppl.tps4144","title":"Randomized phase II study of gemcitabine (G), cisplatin (C) with or without veliparib (V) (arms A, B) and a phase II single-arm study of single-agent veliparib (arm C) in patients with <i>BRCA or PALB2</i>-mutated pancreas adenocarcinoma (PC).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Veliparib; Medicine; Clinical endpoint; Internal medicine; Gemcitabine; Carboplatin; Phases of clinical research; BRCA mutation; Oncology; Urology; Surgery; Cisplatin; Cancer; Randomized controlled trial; Clinical trial; Chemotherapy; Ovarian cancer; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003563723,0.003024793,0.003443974,0.0008839415,0.000657849,0.001863518,0.001674194,0.003498937,0.01322292],"category_scores_gemma":[0.002590314,0.001559682,0.001889112,0.0008652976,0.002249092,0.001838083,0.0006993049,0.005528525,0.00203327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001646983,"about_ca_system_score_gemma":0.003443154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189122,"about_ca_topic_score_gemma":0.002992707,"domain_scores_codex":[0.9987553,0.0006609719,0.00005399072,0.0002640885,0.00007740899,0.0001882597],"domain_scores_gemma":[0.9977427,0.0004537416,0.0004068074,0.0002187499,0.0001145396,0.001063531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9596498,0.02631938,0.0004789231,0.0002836726,0.0003426028,0.00004259,0.00003836569,0.0004091946,0.002923849,0.0001738914,0.001455747,0.007881989],"study_design_scores_gemma":[0.9355748,0.06263617,0.0004717301,0.00001185606,0.00009267813,0.00002439861,0.000009630574,0.0002175085,0.0002536352,0.0001682984,0.0005298026,0.000009550873],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411632,0.003199548,0.002064805,0.002241847,0.001693161,0.03826674,0.005541266,0.0003729991,0.005456447],"genre_scores_gemma":[0.9246179,0.00315008,0.006467417,0.005455607,0.0009750805,0.04189875,0.004863964,0.0001159623,0.01245528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01322292,"threshold_uncertainty_score":0.04423499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05941126104619237,"score_gpt":0.3713309865635099,"score_spread":0.3119197255173175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}