{"id":"W2586573535","doi":"10.1182/blood.v126.23.4175.4175","title":"Ikaros-Dependent Downregulation of MYC with IMiDs in Myeloma (MM) Cells Is Mediated through the Depletion of the Acetylated Chromatin Reader BRD4 at Super-Enhancer Loci","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Enhancer; Biology; Downregulation and upregulation; BRD4; Molecular biology; Chromatin; KLF4; Cancer research; Transcription factor; Bromodomain; Histone; Gene; Genetics; SOX2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222211,0.0002653089,0.0002720029,0.0001801291,0.0001585168,0.0002620249,0.0001708858,0.0001738335,0.001887339],"category_scores_gemma":[0.00005527577,0.0001178176,0.0002989233,0.0002289998,0.000204685,0.0001050873,0.0002200341,0.0005883962,0.0007672291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209766,"about_ca_system_score_gemma":0.0001320322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364499,"about_ca_topic_score_gemma":0.001121857,"domain_scores_codex":[0.9998152,0.00001509246,0.00001844153,0.00005779437,0.00004848489,0.00004502902],"domain_scores_gemma":[0.9999211,0.000008975956,0.00002729792,0.00001424347,0.000008638302,0.00001984771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005381456,0.000008151964,0.000108246,0.0000178571,0.00000252962,0.00001021866,0.000005109738,0.00001974737,0.9993728,0.000015483,0.0000318353,0.0003542445],"study_design_scores_gemma":[0.000006053353,0.00008737649,0.003805438,0.000002140674,0.000007487957,0.00004807983,0.00001281822,0.0002466132,0.9945278,0.00001115784,0.001243502,0.000001564786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890518,0.001396717,0.00412216,0.0001104714,0.00004956805,0.00003609941,0.002830831,0.0003167719,0.002085565],"genre_scores_gemma":[0.9905128,0.0005186714,0.002529356,0.00006748959,0.000008809259,0.00005149907,0.002278163,0.00004693048,0.003986239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887339,"threshold_uncertainty_score":0.006313801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899555465763853,"score_gpt":0.275235077987887,"score_spread":0.2462395233302485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}