{"id":"W2586628822","doi":"10.1021/acscombsci.6b00174","title":"Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2","year":2017,"lang":"en","type":"article","venue":"ACS Combinatorial Science","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; European Federation of Pharmaceutical Industries and Associations; National Cancer Institute; University of North Carolina at Chapel Hill; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Novartis Pharma; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Pfizer","keywords":"Chemistry; Peptidomimetic; Allosteric regulation; Combinatorial chemistry; Stereochemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273278,0.0004258529,0.0002965675,0.0001946579,0.000118341,0.0002910574,0.0003616687,0.0002981457,0.001101315],"category_scores_gemma":[0.0002588468,0.0001889439,0.000191787,0.0001726743,0.0001817391,0.0002745706,0.0002853612,0.0005100153,0.0004391299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003750875,"about_ca_system_score_gemma":0.0001989942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002422444,"about_ca_topic_score_gemma":0.0005973821,"domain_scores_codex":[0.9998887,0.00002217523,0.000009910892,0.00002309608,0.0000309956,0.00002520458],"domain_scores_gemma":[0.9999187,0.00001775882,0.00002402011,0.000005038756,0.00001139349,0.00002294211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003739541,0.0001531416,0.0002031924,0.0002004238,0.00002594115,0.0002052898,0.00004157602,0.006581835,0.9782251,0.001757144,0.0003710242,0.01186139],"study_design_scores_gemma":[0.000292145,0.002055289,0.0006583435,0.00002012326,0.00003648292,0.0004334915,0.00003022862,0.01278036,0.9742744,0.0003483351,0.009042643,0.00002820612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528703,0.003069296,0.03374965,0.0003018947,0.0001031867,0.0003293262,0.0006364671,0.0003621849,0.00857766],"genre_scores_gemma":[0.9788067,0.00159041,0.0161174,0.0001574197,0.00001903304,0.0001494057,0.0004037386,0.00002910483,0.002726899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101315,"threshold_uncertainty_score":0.003684282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008032322464462904,"score_gpt":0.2543221917222153,"score_spread":0.2462898692577524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}