{"id":"W2586682700","doi":"10.3748/wjg.v23.i6.986","title":"Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation","year":2017,"lang":"en","type":"article","venue":"World Journal of Gastroenterology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"National Natural Science Foundation of China","keywords":"Unfolded protein response; Apoptosis; Molecular biology; Tunicamycin; Biology; Small interfering RNA; Endoplasmic reticulum; Chemistry; Cancer research; Cell biology; Cell culture; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006169995,0.0002408295,0.0001758279,0.0001282719,0.0001168524,0.00007744928,0.000110955,0.0001107836,0.0007046839],"category_scores_gemma":[0.00004139319,0.00005769653,0.0001907777,0.0000849181,0.00007205398,0.0001100996,0.00007255649,0.0002242553,0.0001423944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247396,"about_ca_system_score_gemma":0.0001429695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002863767,"about_ca_topic_score_gemma":0.0007623876,"domain_scores_codex":[0.9999738,0.000003258444,0.000003560362,0.00000539587,0.000006921276,0.000007072029],"domain_scores_gemma":[0.9999844,0.000001747499,0.000005211629,0.000001912179,0.000002977772,0.000003764497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004023005,0.00007222297,0.0002294642,0.0001180419,0.000008834932,0.000102098,0.00001064796,0.00003905702,0.9947268,0.00003713125,0.0001226921,0.004130558],"study_design_scores_gemma":[0.0001302472,0.001563411,0.005264895,0.000007726225,0.00005532186,0.0005255612,0.00002039137,0.0005573106,0.9870282,0.00003672775,0.004806676,0.000003546085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831905,0.01053031,0.003920269,0.0001729154,0.0001269407,0.00006363938,0.0003225479,0.0001534923,0.001519308],"genre_scores_gemma":[0.991985,0.004190494,0.001763753,0.0000657069,0.00003552778,0.00004338676,0.0003319251,0.000008702098,0.001575442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007046839,"threshold_uncertainty_score":0.002357364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125292558227795,"score_gpt":0.2675365339840688,"score_spread":0.2550072781612893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}