{"id":"W2586694861","doi":"10.1158/2159-8290.cd-16-1045","title":"Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Centre Technologique des Résidus Industriels","keywords":"Somatic cell; Germline; Biology; Germline mutation; Genetics; PTEN; Cancer; Gene; Cancer research; Mutation; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003908199,0.0001053768,0.0001454321,0.00003557418,0.00004965913,0.00002796153,0.0001780184,0.0000582705,0.00002951056],"category_scores_gemma":[0.00002490007,0.00009200582,0.00004032208,0.00003373584,0.00005216127,0.00001946242,0.00008116876,0.00005456501,9.133238e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004111965,"about_ca_system_score_gemma":0.000182032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001959239,"about_ca_topic_score_gemma":0.005562719,"domain_scores_codex":[0.9994222,0.00001071432,0.0001477282,0.0002011654,0.00007685905,0.0001413656],"domain_scores_gemma":[0.999363,0.000007709275,0.0001931609,0.0003675723,0.00003534421,0.00003323426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004899754,0.0001028318,0.8152879,0.00006690238,0.00009177753,0.000003734868,0.00009409478,0.001434589,0.1781752,0.00003489822,0.0006980714,0.003520038],"study_design_scores_gemma":[0.002010275,0.0002333132,0.8497106,0.0004307711,0.00004858921,0.000004261433,0.0001247976,0.0002044632,0.1439518,0.00009252434,0.002889823,0.0002988057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969561,0.001710143,0.0001154537,0.0002055891,0.0003336112,0.0001298229,0.00009027083,0.000002180402,0.0004568069],"genre_scores_gemma":[0.9973631,0.001811601,0.00003088382,0.0001280543,0.0001928821,0.00008342516,0.00003350772,0.00001778903,0.000338762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0344227,"threshold_uncertainty_score":0.3751888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142478757107829,"score_gpt":0.2830679009464958,"score_spread":0.2688200252357129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}