{"id":"W2586698568","doi":"10.1016/j.jalz.2016.12.012","title":"Transethnic genome‐wide scan identifies novel Alzheimer's disease loci","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; University of California, Irvine; University of California, San Diego; University of California, Davis; University of California, Los Angeles; National Institutes of Health; Rosetrees Trust; Banner Alzheimer’s Foundation; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Johns Hopkins University; University of Washington; Boston University; University of Miami; Northwestern University; New York University; University of Kentucky; Emory University; University of California, San Francisco; Indiana University; University of Pennsylvania; Vanderbilt University; Mayo Clinic; University of Michigan; University of Southern California; Wellcome Trust; Duke University; Columbia University; Rush University; National Institute of Mental Health; National Association for Colitis and Crohn's Disease; University of Alabama at Birmingham; Massachusetts General Hospital; GlaxoSmithKline; Parkinson's UK; University of Arizona","keywords":"Genome-wide association study; Single-nucleotide polymorphism; SNP; Genetics; Locus (genetics); Genetic association; Biology; Genetic architecture; Allele; Apolipoprotein E; Disease; Alzheimer's disease; Gene; Genotype; Medicine; Quantitative trait locus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008647603,0.0003189316,0.0004201453,0.0006493686,0.0007412925,0.0008436012,0.0002973696,0.0003012171,0.002459708],"category_scores_gemma":[0.001112499,0.0001376006,0.0006117637,0.00100191,0.0002343194,0.0001991123,0.0007825941,0.0004131761,0.0001987174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246332,"about_ca_system_score_gemma":0.0002893238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004178173,"about_ca_topic_score_gemma":0.0109331,"domain_scores_codex":[0.9995004,0.0001827855,0.0000454971,0.0001735039,0.00004688165,0.00005096532],"domain_scores_gemma":[0.9992442,0.0001807431,0.0001743989,0.0001218768,0.000126802,0.0001521011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008656075,0.00008916904,0.9484848,0.00005314968,0.001305394,0.0005228645,0.0003312735,0.0002670614,0.03821961,0.0003177912,0.0004389171,0.009104402],"study_design_scores_gemma":[0.00003357662,0.0001481819,0.9921991,0.00001292709,0.0006921063,0.0008031719,0.0003702566,0.0008595365,0.003034345,0.0003787308,0.001456823,0.00001122781],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972615,0.0002852117,0.001190008,0.00007756198,0.000008649879,0.000005470336,0.0006225369,0.000016845,0.0005321886],"genre_scores_gemma":[0.9982886,0.00009752672,0.0007846244,0.00003982658,0.000007972119,0.000008511622,0.0004961038,0.000007155033,0.000269678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004178173,"threshold_uncertainty_score":0.008307695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03272594229589691,"score_gpt":0.2921124801967822,"score_spread":0.2593865379008853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}