{"id":"W2586698568","doi":"10.1016/j.jalz.2016.12.012","title":"Transethnic genome‐wide scan identifies novel Alzheimer's disease loci","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; University of California, Irvine; University of California, San Diego; University of California, Davis; University of California, Los Angeles; National Institutes of Health; Rosetrees Trust; Banner Alzheimer’s Foundation; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Johns Hopkins University; University of Washington; Boston University; University of Miami; Northwestern University; New York University; University of Kentucky; Emory University; University of California, San Francisco; Indiana University; University of Pennsylvania; Vanderbilt University; Mayo Clinic; University of Michigan; University of Southern California; Wellcome Trust; Duke University; Columbia University; Rush University; National Institute of Mental Health; National Association for Colitis and Crohn's Disease; University of Alabama at Birmingham; Massachusetts General Hospital; GlaxoSmithKline; Parkinson's UK; University of Arizona","keywords":"Genome-wide association study; Single-nucleotide polymorphism; SNP; Genetics; Locus (genetics); Genetic association; Biology; Genetic architecture; Allele; Apolipoprotein E; Disease; Alzheimer's disease; Gene; Genotype; Medicine; Quantitative trait locus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000417401,0.0002760745,0.0002618522,0.00004563607,0.0006992843,0.0001151713,0.0007235178,0.0001816341,0.0001649524],"category_scores_gemma":[0.0001563236,0.0002832693,0.00024507,0.00003732368,0.0002545716,0.00001516059,0.000262404,0.000113055,0.00009957408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000380598,"about_ca_system_score_gemma":0.0001135386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729993,"about_ca_topic_score_gemma":0.0002753243,"domain_scores_codex":[0.9982007,0.00008082796,0.000403756,0.0006077624,0.0001722418,0.0005347841],"domain_scores_gemma":[0.9981126,0.00002191217,0.0003156504,0.001184072,0.000113798,0.0002520351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003701089,0.000899422,0.5983979,0.0000227909,0.06674026,0.00003794522,0.0003890578,0.0009072154,0.22059,0.0006366472,0.06729911,0.04370964],"study_design_scores_gemma":[0.0007738989,0.00008394293,0.9147997,0.000005769046,0.008223256,0.000003991616,0.00004291908,0.00009454916,0.009410922,0.0003512941,0.06573349,0.0004761948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7229187,0.2560079,0.009692234,0.004846165,0.001348884,0.0008821327,0.0002963937,0.00006862453,0.003938901],"genre_scores_gemma":[0.9960791,0.0006697368,0.001476208,0.000748936,0.0003254547,0.00007020919,0.0004785833,0.00004378335,0.000107995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3164019,"threshold_uncertainty_score":0.999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03272594229589691,"score_gpt":0.2921124801967822,"score_spread":0.2593865379008853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}