{"id":"W2586740931","doi":"10.1200/jco.2012.30.30_suppl.80","title":"Identification of multifunctional cytotoxic T-cell subsets as immune correlates with clinical outcomes in a phase II study of AGS-003, an autologous dendritic cell-based therapy administered to patients with newly diagnosed, metastatic RCC.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"CTL*; Medicine; Cluster of differentiation; Cytotoxic T cell; Immune system; CD8; T cell; Immunology; Cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003492988,0.0003120743,0.002153307,0.0003714573,0.00009935974,0.000009219427,0.0003980415,0.0004331946,0.0003155287],"category_scores_gemma":[0.001830158,0.00021002,0.0003312668,0.0002617174,0.0004450614,0.0002881144,0.00005408197,0.000960481,0.00003722518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008251585,"about_ca_system_score_gemma":0.0009439601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008626959,"about_ca_topic_score_gemma":0.000288976,"domain_scores_codex":[0.9906282,0.003078156,0.005291868,0.0003614397,0.0002596852,0.0003806935],"domain_scores_gemma":[0.9886457,0.005220813,0.004762756,0.0004377735,0.0007256404,0.000207264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02487863,0.09777647,0.8581859,0.00002323936,0.0005869676,0.0000673381,0.001426847,0.0002270774,0.01260783,0.000005631723,0.00009809363,0.004115963],"study_design_scores_gemma":[0.07400363,0.1154827,0.8009342,0.00004421519,0.000396775,0.00003070104,0.00108751,0.00001954892,0.007483922,0.000006013149,0.0002922685,0.0002184956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963661,0.0002765406,0.0002966069,0.0001101959,0.001673464,0.001198173,0.00004983574,0.0000119106,0.000017181],"genre_scores_gemma":[0.9987438,0.00002316317,0.0006771563,0.0002736987,0.00005360701,0.00004830405,0.00004607491,0.00003174308,0.0001024533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05725171,"threshold_uncertainty_score":0.8564368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06275273621190049,"score_gpt":0.4061925246995126,"score_spread":0.3434397884876121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}