{"id":"W2586785266","doi":"10.1016/j.xphs.2017.02.002","title":"The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Endocrinology; Internal medicine; Kidney; Obesity; Adipose capsule of kidney; Fructose; Calorie; Transporter; Cytochrome P450; Chemistry; Biology; Messenger RNA; Pharmacology; Metabolism; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013376,0.0006056897,0.0003067091,0.0007986351,0.0003661874,0.0002930801,0.0001905751,0.000300368,0.002515454],"category_scores_gemma":[0.000160378,0.0003678897,0.0004551835,0.0003829959,0.0006299447,0.0004328109,0.0002191477,0.0009526214,0.0002236546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803553,"about_ca_system_score_gemma":0.0004124555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002451035,"about_ca_topic_score_gemma":0.005173144,"domain_scores_codex":[0.9998449,0.00001977944,0.00001038627,0.00002991763,0.00002813798,0.00006681243],"domain_scores_gemma":[0.9996871,0.00003809623,0.00006357269,0.00003372034,0.00002348556,0.0001540784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01873304,0.0008630665,0.003875761,0.00006027718,0.00006886936,0.0002076864,0.00008288586,0.0003109535,0.9699708,0.0004075368,0.0001547387,0.00526438],"study_design_scores_gemma":[0.0002068503,0.006082121,0.05592822,0.00001529408,0.0002511734,0.0002739257,0.000385626,0.001057592,0.9339591,0.0003020125,0.001488888,0.00004915726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985215,0.0003514074,0.000272792,0.0000818618,0.00002577001,0.000006304761,0.0003201826,0.0000165639,0.0004036889],"genre_scores_gemma":[0.9937954,0.0008698755,0.0005108658,0.0001034736,0.00002529364,0.00003174125,0.0006243748,0.00002216176,0.004016675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002515454,"threshold_uncertainty_score":0.008415043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661491383283684,"score_gpt":0.3271212885209495,"score_spread":0.3005063746881126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}