{"id":"W2586817040","doi":"10.1016/s0923-7534(21)00602-5","title":"444PD Patient-reported outcomes (PROs) in ASCEND-5: A randomized, phase 3 study of ceritinib vs chemotherapy (CT) in patients (pts) with advanced anaplastic lymphoma kinase rearranged (ALK +) NSCLC previously treated with CT and crizotinib (CRZ)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ceritinib; Medicine; ALK inhibitor; Anaplastic lymphoma kinase; Lung cancer; Pemetrexed; Internal medicine; Docetaxel; Oncology; non-small cell lung cancer (NSCLC); Crizotinib; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001880899,0.001847555,0.002385324,0.000457537,0.0003949842,0.001037019,0.0009718733,0.001440983,0.004951008],"category_scores_gemma":[0.001437983,0.0005052434,0.0032129,0.0004179886,0.001046716,0.001126709,0.0005840573,0.003885227,0.0005963515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001073512,"about_ca_system_score_gemma":0.0009385675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050885,"about_ca_topic_score_gemma":0.002639949,"domain_scores_codex":[0.9991478,0.0004760638,0.00004264944,0.0001310497,0.00006187593,0.0001405915],"domain_scores_gemma":[0.9990195,0.0002265009,0.0002915743,0.00006202087,0.00004623806,0.0003541969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9751354,0.003938,0.001935823,0.00026164,0.001188859,0.00002716896,0.00002740182,0.0008295038,0.001691711,0.00008564242,0.0006684612,0.01421045],"study_design_scores_gemma":[0.8537985,0.1313308,0.01022303,0.00003079316,0.001556258,0.00006618584,0.00003878387,0.001240353,0.0007569744,0.0001955285,0.0007383726,0.00002447912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934515,0.0023684,0.0002956051,0.0004276925,0.0002147585,0.0009170367,0.001045019,0.0000911258,0.00118889],"genre_scores_gemma":[0.9944185,0.0008623202,0.0006497855,0.0004812576,0.0002345673,0.001045911,0.001376043,0.00001565271,0.0009159417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004951008,"threshold_uncertainty_score":0.01656276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149562725861267,"score_gpt":0.3610827920995469,"score_spread":0.3395871648409342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}