{"id":"W2586825521","doi":"10.1021/acs.jmedchem.6b01668","title":"Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Graduate Education; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research","keywords":"Metabolite; In vivo; Chemistry; In vitro; Insulin; Secretion; Carboxylic acid; Metabolism; Biochemistry; Internal medicine; Endocrinology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006817062,0.0001877929,0.0005501549,0.0001110969,0.00003244848,0.00001351045,0.0002350851,0.0002157856,0.00001235579],"category_scores_gemma":[0.0008356262,0.000161442,0.00007400278,0.00007032825,0.00020093,0.0000159433,0.00006697612,0.0002144251,8.859602e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006067845,"about_ca_system_score_gemma":0.0000780511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001535616,"about_ca_topic_score_gemma":0.000002431522,"domain_scores_codex":[0.9986471,0.00009730695,0.0005753364,0.0002228697,0.0002895468,0.0001678656],"domain_scores_gemma":[0.9986759,0.00005213281,0.0007662423,0.0002943587,0.000107637,0.0001037156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009087305,0.0000755967,0.004328188,0.0004097337,0.0000457311,0.00001119877,0.0001313709,0.000001383952,0.977774,0.000002293349,0.000003856097,0.01630794],"study_design_scores_gemma":[0.001910976,0.000120488,0.1278672,0.0003183035,0.00007501041,0.00002661371,0.00009264681,0.00002223897,0.869229,0.0000382095,0.0001874075,0.000111891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994715,0.004510026,0.00003859477,0.0002551112,0.0001203094,0.0001148999,0.00001660882,0.000001096235,0.0002283823],"genre_scores_gemma":[0.9952797,0.004274697,0.000143604,0.00005135841,0.0002034676,0.000006283939,0.000007828552,0.00001543753,0.00001762459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.123539,"threshold_uncertainty_score":0.6583416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005380299748668983,"score_gpt":0.230958243478761,"score_spread":0.225577943730092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}