{"id":"W2586825521","doi":"10.1021/acs.jmedchem.6b01668","title":"Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Graduate Education; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research","keywords":"Metabolite; In vivo; Chemistry; In vitro; Insulin; Secretion; Carboxylic acid; Metabolism; Biochemistry; Internal medicine; Endocrinology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289795,0.0003595283,0.0002366215,0.0002305995,0.0001625683,0.0001343052,0.0002157738,0.0003116223,0.00151553],"category_scores_gemma":[0.0002631668,0.000100213,0.000252623,0.0003832819,0.0001335201,0.0002692832,0.0001453137,0.0003473758,0.0005002285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145851,"about_ca_system_score_gemma":0.00036619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005331417,"about_ca_topic_score_gemma":0.0005596048,"domain_scores_codex":[0.9998699,0.00003303279,0.000008506782,0.0000226056,0.00002344255,0.00004243351],"domain_scores_gemma":[0.9998268,0.00002553072,0.00004264678,0.00002285545,0.00003518844,0.00004691549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003203182,0.00007753617,0.0001133953,0.00007428756,0.000007599866,0.0001261116,0.00002707777,0.0004749636,0.9927465,0.0001815551,0.00004513944,0.005805451],"study_design_scores_gemma":[0.00002064581,0.000586369,0.0006993572,0.000006514322,0.00001019843,0.0001089297,0.00001153374,0.0002331713,0.9947989,0.00002950184,0.00348895,0.000005924946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678067,0.004884368,0.02034862,0.0001400755,0.00006416692,0.0003224305,0.001388477,0.00007460037,0.004970665],"genre_scores_gemma":[0.9714941,0.003482117,0.01808938,0.00008655417,0.00002448159,0.0001525193,0.001746319,0.0000547564,0.004869915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151553,"threshold_uncertainty_score":0.005069971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005380299748668983,"score_gpt":0.230958243478761,"score_spread":0.225577943730092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}