{"id":"W2586859590","doi":"10.1182/blood.v114.22.31.31","title":"Novel Mechanistic Insight Into Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs): Complement Cascade and Membrane Attack Complex Activated in Bone Marrow Sinusoids During Mobilization Release From Erythrocytes Sphingosine-1 Phosphate – An Underappreciated Chemoattractant Executing Egress of HSPCs.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Haematopoiesis; Bone marrow; Progenitor cell; Complement membrane attack complex; Cell biology; Chemistry; Myelopoiesis; Complement system; Stem cell; Immunology; Biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001819428,0.00035076,0.0008751404,0.0002443684,0.000113138,0.00002014841,0.0001095253,0.0002156076,0.00008647297],"category_scores_gemma":[0.00005181357,0.0003431697,0.00007848332,0.0005327766,0.0001008041,0.0001624571,0.00005093965,0.0002139555,0.00000141593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009720165,"about_ca_system_score_gemma":0.00008658256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002690172,"about_ca_topic_score_gemma":0.00007397648,"domain_scores_codex":[0.9976282,0.0001238011,0.00101039,0.0005757279,0.000341358,0.0003205683],"domain_scores_gemma":[0.9984588,0.0001247711,0.0005741692,0.000406091,0.0002621645,0.0001739885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009513142,0.00276,0.001009621,0.0007125746,0.0001000274,0.00003577569,0.001702574,0.0006624298,0.9916242,0.00005364326,0.000004209882,0.0003835748],"study_design_scores_gemma":[0.008697962,0.000827504,0.01943898,0.0006380788,0.0002646782,0.00007134707,0.0008069113,0.008896443,0.9600181,0.00004344386,0.00001104262,0.0002854954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973479,0.0005769618,0.0007856307,0.00005419266,0.00010005,0.0009695914,0.00004877057,0.0000838296,0.0000330717],"genre_scores_gemma":[0.99692,0.000223448,0.002143243,0.0001046406,0.00006590836,0.0000202676,0.0004619846,0.00004555935,0.00001490514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03160615,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02928521248660082,"score_gpt":0.2671580597054164,"score_spread":0.2378728472188156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}