{"id":"W2586871870","doi":"10.1242/dmm.027367","title":"Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds","year":2017,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McMaster University Medical Centre","funders":"Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Université Pierre et Marie Curie; Institut National de la Santé et de la Recherche Médicale; Association Française contre les Myopathies","keywords":"Myotonic dystrophy; Immortalised cell line; Biology; Myocyte; RNA splicing; Cell biology; Cell culture; MyoD; Muscular dystrophy; Cell type; Cell; Genetics; Molecular biology; RNA; Myogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0001394308,0.0005228643,0.0004182391,0.0001556212,0.001592112,0.0007494093,0.00166856,0.00007032488,0.0001334031],"category_scores_gemma":[0.0001173597,0.0005032179,0.0003022957,0.000136472,0.000163765,0.0004460114,0.000490084,0.0001702587,0.000165578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005518811,"about_ca_system_score_gemma":0.0001728819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003309828,"about_ca_topic_score_gemma":0.0000103307,"domain_scores_codex":[0.9963891,0.000279046,0.0004025451,0.00132642,0.0008613569,0.0007415253],"domain_scores_gemma":[0.9964548,0.00006359542,0.0002720312,0.002124658,0.0001473706,0.0009375059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008151266,0.0004417734,0.00004972244,0.00003792892,0.000008555988,0.000097686,0.00008257027,0.003971197,0.9585664,0.03637217,0.00008118749,0.0002092708],"study_design_scores_gemma":[0.001096295,0.000178887,0.004617404,0.00003224522,0.0001378901,0.000001489952,0.00002975691,0.02190236,0.8877916,0.08342405,0.0001346062,0.0006533797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578673,0.00007983965,0.03807667,0.0003803395,0.0005235638,0.001037846,0.0002719278,0.0002234714,0.001539099],"genre_scores_gemma":[0.9954028,0.00002035211,0.0008463376,0.002326814,0.000133995,0.0003637169,0.00002481608,0.0001222937,0.0007588522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0707748,"threshold_uncertainty_score":0.999742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197398039668374,"score_gpt":0.3325039969860812,"score_spread":0.2127641930192437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}