{"id":"W2586871870","doi":"10.1242/dmm.027367","title":"Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds","year":2017,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McMaster University Medical Centre","funders":"Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Université Pierre et Marie Curie; Institut National de la Santé et de la Recherche Médicale; Association Française contre les Myopathies","keywords":"Myotonic dystrophy; Immortalised cell line; Biology; Myocyte; RNA splicing; Cell biology; Cell culture; MyoD; Muscular dystrophy; Cell type; Cell; Genetics; Molecular biology; RNA; Myogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197735,0.000591528,0.000634441,0.0003612321,0.0002397918,0.0003433412,0.000310588,0.0004847899,0.002748831],"category_scores_gemma":[0.0002322422,0.0001673705,0.0003803444,0.0003660678,0.0001480697,0.0001982379,0.0002798244,0.001079682,0.002008192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294021,"about_ca_system_score_gemma":0.0002248535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004216229,"about_ca_topic_score_gemma":0.0008460258,"domain_scores_codex":[0.9995659,0.00005921779,0.00005603207,0.0000841738,0.0001927353,0.00004198197],"domain_scores_gemma":[0.9998385,0.0000277715,0.00002597481,0.00002926437,0.00005778364,0.00002068244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007992089,0.00005933809,0.0002165795,0.0001698858,0.00001755587,0.00008242491,0.00003106164,0.0001411494,0.9960014,0.0002208577,0.0005238111,0.002456054],"study_design_scores_gemma":[0.00004105358,0.0005882145,0.002458244,0.00003461799,0.00008310943,0.0004881153,0.00004974556,0.001195784,0.965684,0.0001369246,0.02922276,0.00001732757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7930615,0.02415996,0.1240431,0.0007635497,0.001087973,0.001687025,0.03554197,0.001668769,0.01798608],"genre_scores_gemma":[0.8211535,0.01562989,0.06836427,0.0008733965,0.0001403619,0.002707503,0.06025125,0.0004229151,0.03045692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002748831,"threshold_uncertainty_score":0.009195685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197398039668374,"score_gpt":0.3325039969860812,"score_spread":0.2127641930192437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}