{"id":"W2586921579","doi":"10.1093/annonc/mdw383.30","title":"Time-to-treatment failure (TTF) with first-line afatinib (A) vs gefitinib (G) in patients (pts) with EGFR mutation-positive (EGFRm+) advanced non-small-cell lung cancer (NSCLC): Randomized phase IIb LUX-lung 7 (LL7) trial","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; McGill University","funders":"","keywords":"Medicine; Afatinib; Internal medicine; Clinical endpoint; Gefitinib; Lung cancer; Tolerability; Population; Oncology; Randomized controlled trial; Gastroenterology; Cancer; Adverse effect; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001222549,0.001158735,0.002316802,0.0002874224,0.0002844816,0.001122069,0.0007745355,0.001418765,0.003750725],"category_scores_gemma":[0.001208547,0.0003355108,0.002257555,0.0002698491,0.000871337,0.001177356,0.0003780042,0.003459177,0.0007734863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009351296,"about_ca_system_score_gemma":0.0009661213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00111768,"about_ca_topic_score_gemma":0.003666629,"domain_scores_codex":[0.9996251,0.0001793476,0.00001893227,0.00006960507,0.00002194003,0.00008500957],"domain_scores_gemma":[0.9993061,0.000179972,0.000135387,0.00003438677,0.00003078626,0.0003135076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9401395,0.003261465,0.003234231,0.0008044885,0.002064324,0.00007657944,0.00008560809,0.001709779,0.003377369,0.0003333589,0.003295634,0.04161777],"study_design_scores_gemma":[0.8613773,0.1242713,0.007813939,0.00009328197,0.001764059,0.0001524111,0.00009204313,0.001707034,0.000689649,0.0005757394,0.001423345,0.00003995958],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904335,0.004984791,0.0002586649,0.000890013,0.000308451,0.0004034377,0.0008030554,0.00009219113,0.001826018],"genre_scores_gemma":[0.9929537,0.001889659,0.0003935966,0.0009464312,0.0002495954,0.0004331076,0.001112482,0.0000190899,0.002002218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003750725,"threshold_uncertainty_score":0.01254737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587110195835063,"score_gpt":0.3653018583413047,"score_spread":0.3494307563829541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}