{"id":"W2586934550","doi":"10.1093/annonc/mdw435.40","title":"KEYNOTE-024: Pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) as first-line therapy for advanced NSCLC with a PD-L1 tumor proportion score (TPS) ≥50%","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"","keywords":"Carboplatin; Medicine; Pemetrexed; Pembrolizumab; Oncology; Internal medicine; Gemcitabine; Lung cancer; Cisplatin; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001103163,0.0005941248,0.001233706,0.000391964,0.0002727372,0.0009840718,0.001060369,0.001456309,0.02110729],"category_scores_gemma":[0.001763102,0.0003024138,0.00148314,0.0004278626,0.0003118597,0.001058041,0.0004358119,0.003249368,0.002285222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001159204,"about_ca_system_score_gemma":0.001021152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008767546,"about_ca_topic_score_gemma":0.002946521,"domain_scores_codex":[0.9997017,0.0001126364,0.00003165394,0.00005452343,0.000034603,0.00006486875],"domain_scores_gemma":[0.9993237,0.0002061042,0.000115668,0.00002602882,0.00004580615,0.0002825909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7691725,0.003389252,0.002667168,0.001603932,0.001595013,0.0002448377,0.00006352177,0.001692883,0.007245264,0.001010291,0.03591732,0.1753981],"study_design_scores_gemma":[0.727159,0.1472267,0.03297465,0.0007946486,0.006379326,0.000861483,0.0001720449,0.004390181,0.006433217,0.002409724,0.07109387,0.0001053326],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8468395,0.03728784,0.001749026,0.02534558,0.01573421,0.003819429,0.01717859,0.0004942786,0.05155145],"genre_scores_gemma":[0.9408497,0.009318893,0.002848435,0.008061846,0.004787143,0.001451115,0.007625832,0.00009148232,0.0249657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02110729,"threshold_uncertainty_score":0.07061088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04888819655693708,"score_gpt":0.3542047379682811,"score_spread":0.305316541411344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}